Neutrophil chemotactic factor

NCF Neutrophil chemotactic factor NDGA Nordihydroguaretic acid NDP Nucleoside diphosphate Neca 5 -(N-ethyl carboxamido)-adenosine NED Nedocromil sodium NEP Neutral endopeptidase (EC 3.4.24.11)... 

Yoshimura T, Matsushima K, Tanaka S, et al. Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci U S A 1987 84 9233-9237. 

Jagels MA, Hugli TE. Neutrophil chemotactic factors promote leukocytosis. J Immunol 1992 148 1119-1128. 

Mast cell degranulation in response to allergens results in release of mediators such as histamine eosinophil, and neutrophil chemotactic factors leukotrienes C4, D4, and E4 prostaglandins and platelet-activating factor (PAF). Histamine is capable of inducing smooth muscle constriction and bronchospasm and may play a role in mucosal edema and mucus secretion. 

Alveolar macrophages release a number of inflammatory mediators, including PAF and leukotrienes B4, C4, and D4. Production of neutrophil chemotactic factor and eosinophil chemotactic factor furthers the inflammatory process. 

Djeu, J. Y., Matsushima, K., Oppenheim, J. J., Shiotsuki, K., Blanchard, D. K. (1990). Functional activation of human neutrophils by recombinant monocyte-derived neutrophil chemotactic factor/IL-8. J. Immunol. 144, 2205-10. 

Eosinophil chemotactic factor Neutrophil chemotactic factor... 

Smooth muscle contraction Vasodilation Increased vascular permeability Platelet aggregation Complement activation Eosinophil and neutrophil chemotactic factor Mucus secretion... 

MW—molecular weight synonym of the molecular mass (abbreviated M)—is the mass of one molecule NALT—nose-associated lymphoid tissue nanoLC-MSMS—nanoliquid chromatography-tandem MS NCF—neutrophil chemotactic factors NFA—nuclear factor of activated T-lymphocytes NF-kappaB—nuclear factor kappa B NK—cells natural killer cells NMR—nuclear magnetic resonance... 

Marasco, W. A., Phan, S. H., Krutzsch, H., Showell, H. J., Feltner, D. E., Nairn, R., Becker, E. L., and Ward, P. A. (1984). Purification and identification of formyl-methionyl-leucyl-phenylalanine as the m or peptide neutrophil chemotactic factor produced by Escherichia coli. J. Biol. Chem. 259, 5430-5439. 

With each blink the antigen-coated contact lens mechanically traumatizes the tarsal conjunctiva. This process causes the release of mediators, such as neutrophil chemotactic factor and eosinophil chemotactic factor, which attract inflammatory cells (e.g., neutrophils, eosinophils, mast cells, and basophils). The immunologic sequence of events results in an increase in tear immunoglobulins IgE and IgG and C3 anaphylatoxin. The tear immunoglobulins and C3 anaphylatoxin then interact with the inflammatory cells produced from the mechanical trauma. This interaction causes the release of vasoactive amines, resulting in subsequent clinical manifestations. Papillae formation is related to structural changes in the conjunctival epithelium and stroma associated with increased eosinophils and inflammatory cells. 

Hayes AA, Venaille TJ, Rose AH, et al. 1990. Asbestos-induced release of a human alveolar macrophage-derived neutrophil chemotactic factor. Exp Lung Res 16 121-130. 

Yoshimura T, Matsushima K, Oppenheim JJ, Leonard EJ (1987) Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes Partial characterization and separation from interleukin 1 (IL 1). J Immunol 139 788-793. 

Interleukin-8 (IL-1) the major neutrophil chemotactic factor in lung. Exp. Lung Res. 17, 17-23. 

Locally generated chemotactic fector inhibitors could inactivate neutrophil chemotactic factors. Agents with the capacity to inactive C5a activity in vitro have been isolated in plasma (Berenberg and Ward, 1973), but these feaors have not been characterized and quantified at inflamed sites, and a plasma-derived inactivator is unlikely to account for cessation of neutrophil emigration in situations where extravascular protein leakage is minimal or absent. 

Neutrexin trimetrexate. neutrophil chemotactic factor (human isoform) interleukin-8. 

Neutrophil chemotactic factor Eosinophil chemotactic factor Kinins... 

Based on the fact that interleukin-1 (IF-1) induces migration of leukocytes to sites of injection, IF-1 was thought to have chemotactic activity. In fact, leukocyte-derived chemoattractants for phagocytic cells were present in partially purified preparations of IF-1 (Fuger et al, 1983 Sauder et al, 1984). However, when purified to homogeneity, IF-1 lost its chemotactic activity. Further studies revealed that the partially purified IF-1 preparations were contaminated with both a chemotactic factor for monocytes and a monocyte-derived neutrophil chemotactic factor, termed MDNCF (Yoshimura et al, 1987, 1989 Matsushima et al, 1988, 1989). These paradoxical observations were resolved by data showing that IF-1 was a potent inducer of these chemotactic factors. The same mononuclear cell-derived neutrophil attrac-tants were also identified by several other laboratories of (Schroder et al, 1987 Walz et al, 1987). Eater, Farsen et al (1989) reported that MDNCF was chemotactic for T lymphocytes as well as neutrophils, and, based on the presumed involvement of MDNCF in the immune response, it was renamed IF-8 (Farsen et al, 1989 Oppenheim et al, 1991). 

Matsushima, K., Morishita, K., Yoshimura, T., Lavu, S., Kobayashi, Y., Lew, W., Appella, E., Kung, H. F., Leonard, E., and Oppenheim, J. J. (1988). Molecular cloning of cDNA for a human monocyte derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCE mRNA by interleukin 1 and tumor necrosis factor. J. Exp. Med. 167, 1883-1893. 

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