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Eosinophil chemotactic factors of anaphylaxis

ECF-A Mast cells (Eosinophilic chemotactic factor of anaphylaxis) attracts eosinophils small peptide... [Pg.553]

Eosinophils are attracted by proteins released by T cells, mast cells and basophils [eosinophil chemotactic factor of anaphylaxis (ECF-A)]. They bind schistosomulae coated with IgG or IgE, degranulate and release major basic protein, which is toxic. Eosinophils also release histaminase and aryl sulfatase, which inactivates histamine and Slow reacting substance of anaphylaxis (SRS-A). This results in antiinflammatory effects and inhibits migration of granulocytes to the site of injury. [Pg.18]

DDBJ—see EMBL DLS—dynamic light scattering DM—donkey s milk DNA—deoxyribonucleic acid DNCB—2,4-dinitrochlorobenzene DSC—differential scanning calorimetry DTH—delayed cellular hypersensitivity DXMS—deuterium exchange mass spectrometry EAACI—European Academy of Allergology and Clinical Immunology EAR—early anaphylactic phase ECFA—eosinophil chemotactic factors of anaphylaxis ECP—eosinophil cationic protein EDN—eosinophil-derived neurotoxin eHF—extensively hydrolyzed formula ELISA—enzyme-linked immunosorbent assay... [Pg.449]

Concerning mediators of immediate hypersensitivity, the most important include histamine, leukotriene e.g., SRS-A (slow-reacting substance of anaphylaxis, ECF-A (eosinophil chemotactic factor of anaphylaxis), PAF (platelet-activating factor), and serotonin. There are also three classes of lipid mediators that are synthesized by activated mast cells through reactions initiated by the actions of phospholipase A2. These are prostaglandins, leukotrienes, and platelet-activating factors (PAF). [Pg.175]

The eosinophil chemotactic factor of anaphylaxis (ECP-A) is a preformed product pund in rat mast cell granules, in human lung, nasp polyps, and PMN. The activity resides in two acidic tetrapeptides, Ala-Glp Ser-Glu and Val-Gly-Ser-Glu, which preferentially attract eosinophils. Synthetic peptides of this gomposition are equipotent to natural ECF-A botjj in vitro and in vivo. ECF-A shopg maximal chemotactic activity at 10 M, and concentrations as low as 10 M deactivate eosinophils tp sph-sequent stimulation by chemotactic concentrations of ECF-A and C5a. ... [Pg.153]

Eosinophil chemotactic factor (ECF-A) (bronchoconstrictors, factor of anaphylaxis)... [Pg.185]

See other pages where Eosinophil chemotactic factors of anaphylaxis is mentioned: [Pg.433]    [Pg.70]    [Pg.147]    [Pg.433]    [Pg.70]    [Pg.147]    [Pg.1186]    [Pg.1332]    [Pg.1601]    [Pg.90]    [Pg.58]    [Pg.2441]    [Pg.1601]    [Pg.201]    [Pg.87]    [Pg.45]   
See also in sourсe #XX -- [ Pg.6 ]



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Eosinophile

Eosinophilic

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