Neuropathological

Mashorer E, Soreq H (2006) Virtues and woes of AChE alternative splicing in stress-related neuropathologies. Trends Neurosci 29(4) 216-224... [Pg.361]

Siegel JM (2004) Hypocretin (orexin) role in normal behavior and neuropathology. Annu Rev Psychol 55 125-148... [Pg.913]

Harper SQ, Staber PD, He X et al (2005) RNA interference improves motor and neuropathological abnormalities in a Huntington s disease mouse model. Proc Natl Acad Sci USA 102(16) 5 820-5 825... [Pg.1094]

Neurotoxicity is the major end-point for the methyl-tins, with a NOAEL of approximately 0.6 mg/kg body weight based on neuropathology for dimethyltin limited data for monomethyltin preclude the derivation of a NOAEL. No neurotoxicity was found with dibutyltin or mono- and dioctyltins no information is available for monobutyltin. [Pg.5]

Dimethyltin Yes. NOAEL = 0.6 (neuropathology) mg/kg body weight per day (as DMTC) Yes. NOAEL =10 (maternal and fetal toxicity) mg/kg body weight per day (as DMTC) No data available Limited data thymus weight unaffected at 5 mg/kg body weight per day (as DMTC)... [Pg.39]

O. Meucci (ed.), Chemokine Receptors and NeuroAIDS Beyond Co-Receptor Function and Links to Other Neuropathologies, DOI 10.1007/978-l-4419-0793-6 l,... [Pg.3]

Budka H (1989) Human immunodeficiency virus (HlV)-induced disease of the central nervous system pathology and implications for pathogenesis. Acta Neuropathol 77(3) 225-236 Budka H (1991) Neuropathology of human immunodeficiency vims infection. Brain Pathol 1(3) 163-175... [Pg.22]

Lentz MR, Kim JP, Westmoreland SV, Greco JB, Fuller RA, Ratal EM, He J, Sehgal PK, Halpern EF, Lackner AA, Masliah E, Gonzalez RG (2005) Quantitative neuropathologic correlates of... [Pg.26]

The electrophysiological and neuropathological changes are similar to the axonal neuropathy and prominent loss of unmyelinated fibers seen in DSP (Simpson and Tagliati 1995). Although the specific pathological mechanisms of ATN are not fully known, there is abundant indirect evidence of mitochondrial dysfunction as a principal mechanism. Prominent mitochondrial disruption and cristae abnormalities... [Pg.57]

The neuropathological analysis of HIV-associated neuropathies should include the different central and peripheral nervous system structures associated with sensory pathways, including spinal cord, dorsal root ganglia (DRG), peripheral nerve, and cutaneous nerve fibers (Pardo et al. 2001) (Fig. 4.1). The majority of studies have focused on the evaluation of the peripheral nerve, often from sural nerve biopsies and the DRG. Few studies have examined the pathology of sensory pathways in the... [Pg.63]

Franklin RJ (2002) Why does remyehnation fail in multiple sclerosis Nat Rev Neurosci 3 705-714 Fratkin JD, Leis AA, Stokic DS, Slavinski SA, Geiss RW (2004) Spinal cord neuropathology in human West Nile virus infection. Arch Pathol Lab Med 128 533-537 Frohman EM, Racke MK, Raine CS (2006) Multiple sclerosis - the plaque and its pathogenesis. N Engl J Med 354 942-955... [Pg.138]

Chemokine Signaling in the Nervous System and Its Role in Development and Neuropathology... [Pg.191]

Neuropathology of AIDS is thought be a result of complex interactions of both viral and host factors that directly or indirectly cause neuronal loss as well as other manifestations associated with neuroAIDS (Jones and Power 2006). The HIV envelope... [Pg.232]

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