Prion diseases neuropathology

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DeArmond SJ, Ironside JW. Neuropathology of prion diseases. In Prusiner SB, ed. Prion Biology and Diseases. Vol. 38. Cold Spring Harbor, NY Cold Spring Harbor Press, 1999 585-652. 

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The increasing growth of neuropathologies, especially in Western countries, which are associated with prions and other aggregates of misfolded proteins, has become a serious concern in biomedical research. Amyloid fibril formation, for instance, appears to be the critical step in Alzheimer s disease. Ultrasound has been used to evaluate both the formation and disruption of amyloids, although contradictory results may be found as sonication parameters are often overlooked, as in biofilms. 

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