Neuropathology nerve cell changes

In three cases of Banker et al. (1962) neuropathological changes consisted of a mild neuronal cytoplasmic accumulation of a glycolipid, nerve cell loss, and neuro-nophagia in the brain stem nuclei. In addition, there were foci of nerve cell loss in layers three and five of the cortex as well as infiltrates of Gaucher cells and microglia in these zones. 

Thus, the neuropathological studies confirm that serious, but nonspecific damage to the nervous system occurs in poisoning with organic lead compounds. The nerve cells in the hippocampus, reticular formation, and cerebellum may be particularly sensitive to Et4Pb. This is in agreement with cHnical effects upon memory, attention level, psychomotor, and EEG changes. 

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