Neuropathological disorder

Davies SW, Beardsall K, Turmaine M, DiFiglia M, Aronin N, Bates GP. Are neuronal intranuclear inclusions the common neuropathology of triplet-repeat disorders with polyglutamine-repeat expansions Lancet 1998 351 131-133. 

Johnston-Wilson NLet al. Disease-specific alterations in frontal cortex brain proteins in schizophrenia, bipolar disorder, and major depressive disorder. The Stanley Neuropathology Consortium. Mol Psychiatry 2000 5 142-149. 

Kato, S. etal. Amyotrophic lateral sclerosis, in D. Dickson (ed.), Neurodegeneration - The Molecular Pathology of Dementia and Movement Disorders. Basel ISN Neuropathology Press, 2003, pp. 350-368. 

Gibb WRG. (1998). The neuropathology of parkinsonian disorders. In Parkinson s Disease and Movement Disorders, 3rd ed. Jankovic J, Tolosa E, ed. Baltimore Williams and Wilkins. 

Protein aggregation is a common feature of all of the chronic human neurode-generative disorders. The intraneuronal inclusions in many of these diseases contain deposits of ubiquitylated proteins, indicating that perturbations of ubiquitin-dependent proteolysis may occur. The neuropathological hallmarks of AD are intraneuronal NFTs composed of hyperphosphorylated protein tau and extracellular amyloid plaques (12,23,24,191,207). Most of the ubiquitylated, hyperphosphorylated tau protein in NETs is monoubiquitylated, with the remainder polyubiquitylated, as the substrate of the 26S proteasome (258). The protein deposits in NET, neuritic plaques, and neuropil threads in the cerebral cortex of AD patients and those with... 

The neurodevelopmental hypothesis of schizophrenia posits that the disorder is due to a subtle defect in prenatal brain development but is not clinically manifest until many years later (Murray and Lewis, 1987 Weinberger, 1987). This theory has two essential components a presumption of developmental neuropathology and an expectation that this developmental neuropathology results in a pattern of brain malfunction which ultimately produces the symptoms of schizophrenia. 

Terry RD Alzheimer s disease, in Textbook of Neuropathology. Edited by Davis RL, Robertson DM. Baltimore, MD, Williams Wilkins, 1985, pp 824-841 Tesar GE, Rosenbaum JF Recognition and management of panic disorder. Adv Intern Med 28 123-149, 1993... 

Before the development of brain imaging techniques, neuroanatomical correlates were primarily related to structural lesions of the CNS. Despite the fact that abnormalities have been found in both schizophrenia and affective illness, interest in the neuropathology of mood disorders has not been as intense as for schizophrenia. 

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