Neuronal adhesions

Lotari M, Solomon A, Ben-Bassat S, Schwartz M (1994) Cytokines modulate die inflammatory response and change permissiveness to neuronal adhesion in injured mammalian central nervous system. Exp Neurol 126 284—290. 

Budreck, EC and Scheiffele, P (2007) Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. Eur J Neurosci 26 1738-1748. 

Interestingly, polysialic acid is a rather labile substance, which easily degrades spontaneously even under physiological conditions, due to an anomalously high p/f value of the internal sialic acid residues [258], This intramolecular self-cleavage may influence neuronal adhesion, embryogenesis and bacterial virulenee. 

Friedlander, D.R, Milev, P., Karthikeyan, L., Margolis, R.K., Margolis, R.U. and Grumet, M. (1994) The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/Ll/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J. Cell Biol. 125 669-680. 

Cadherins are a superfamily of Ca2+-sensitive cell-cell adhesion molecules, which cause homophilic cell interactions. Cadherins can be divided into different subfamilies, namely, classical cadherins, desmosomal cadherins, protocadherins, and nonconventional cadherins (7TM cadherins, T-cadherin, FAT). Classical cadherins are often denoted by a prefix reflecting their principal expression domains e.g., E is epithelial, N is neuronal, and P is placental. However, this classification is not stringent, as for instance E-cadherin can also be found in certain neuronal tissues, and N-cadherin is also found in epithelial cells. Among the desmosomal cadherins, two subfamilies can be distinguished the desmocollins 1-3 and the desmogleins 1-4. 

Fak (focal adhesion kinase) is expressed in most tissues and is evolutionary conserved across species. It is activated by integrin clustering and by stimulation of several G protein-coupled recqrtors and RTKs. Fak is associated with focal adhesions and regulates cell spreading and migration. The kinase is essential for embryonic development since the homozygote Fak knockout is embryonic lethal. Pyk2 (proline-rich tyrosine kinase 2), the second member of the Fak kinase family has a more restricted expression pattern (primarily neuronal and hematopoietic cells) and does not localize to focal adhesions. 

Proudfoot AE, Buser R, Borlat F et al (1999) Amino-terminally modified RANTES analogues demonstrate differential effects on RANTES receptors. J Biol Chem 274 32478-32485 Qin AP, Zhang HE, Qin ZH (2008) Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death. Neurosci Bull 24 117-123 Richter R, Bistrian R, Escher S et al (2005) Quantum proteolytic activation of chemokine CCL15 by neutrophil granulocytes modulates mononuclear cell adhesiveness. J Immunol 175 1599-1608... 

Lauro C, Catalano M, Trettel F et al (2006) The chemokine CX3CL1 reduces migration and increases adhesion of neurons with mechanisms dependent on the betal integrin subunit. J Immunol 177 7599-7606... 

Jung H, Toth PT, White PA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104 254-263 Kahn L, Alonso G, Normand E, Manzoni OJ (2005) Repeated morphine treatment alters polysia-lylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and ceU proliferation in the adult rat hippocampus. Em J Nemosci 21 493-500 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ (2) 296-305... 

Neuron-glial adhesion in nerve cell cultures is mediated by the pi subunit AMOG (adhesion molecule on glia) in the aipi isozyme of Na,K-ATPase [51]. Antibodies to the pi subunit dissociate cell-cell associations and also increase the rate of active... 

Schwanzel-Fukuda M., Reinhard G.R., Abraham S., Crossin K.L., et al. (1994). Antibody to neural cell adhesion molecule can disrupt the migration of luteinizing hormone-releasing hormone neurons into the mouse brain. J Comp Neurol 342, 174-185. 

Deficient for NK cell recruitment Mediates harmful neuron-microglial adhesion... 

Regan CM. 1993. Neural cell adhesion molecules, neuronal development and lead toxicity. Neurotoxicology 14 69-74. 

MYELIN FORMATION, STRUCTURE AND BIOCHEMISTRY 51 MEMBRANE TRANSPORT 73 ELECTRICAL EXCITABILITY AND ION CHANNELS 95 CELL ADHESION MOLECULES 111 THE CYTOSKELETON OF NEURONS AND GLIA 123... 

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