Neural Cell-adhesion Molecule

Jung H, Toth PT, White PA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104 254-263 Kahn L, Alonso G, Normand E, Manzoni OJ (2005) Repeated morphine treatment alters polysia-lylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and ceU proliferation in the adult rat hippocampus. Em J Nemosci 21 493-500 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ (2) 296-305... 

NAP-I, NAP-2 Neutrophilactivating peptides -1 and -2 NBT Nitro-blue tetrazolium NCI Non-collagen 1 N-CAM Neural cell adhesion molecule... 

Fig. 4.6(a) Migration of LHRH neurocrine cells prenatal transportation along the track of extra-bulbar VN axons (caudal branch). CB, cribriform plate FB, forebrain cell types, TAG-1, transient axonal surface glycoprotein and N-CAM, neural cell adhesion molecule (from Yoshida et al, 1995). 

Schwanzel-Fukuda M., Reinhard G.R., Abraham S., Crossin K.L., et al. (1994). Antibody to neural cell adhesion molecule can disrupt the migration of luteinizing hormone-releasing hormone neurons into the mouse brain. J Comp Neurol 342, 174-185. 

Yoshihara Y Kawasaki M., Tamada A., Fujita H., et al. (1997). OCAM a new member of the neural cell adhesion molecule family related to zone-to-zone projection of olfactory and vomeronasal axons. J Neurosci 17, 5830-5842. 

Jones, F. S., Prediger, E. A., Bittner, D. A., DeRobertis, E. M., and Edelman, G. M. (1992b). Cell adhesion molecules as targets for Hox genes neural cell adhesion molecule promoter activity is modulated by cotransfection with Hox-2.5 and -2.4. Proc. Natl. Acad. Sci. USA 89 2086-2090. 

Regan CM. 1993. Neural cell adhesion molecules, neuronal development and lead toxicity. Neurotoxicology 14 69-74. 

Many transmembrane proteins that mediate intracellular signaling form complexes with both intra- and extracellular proteins. For example, neural cell adhesion molecules (NCAMs) are cell-surface glycoproteins (Ch. 7). The extracellular domains of NCAMs can activate fibroblast growth factor receptors when clustered by reaction with NCAM antibodies [4] or by homotypic binding to domains of adjacent cells (see Fig. 7-2). Activation was found to sequester a complex of NCAM, (31 spectrin and PKC(32 into rafts, as defined by the operational criteria discussed on p. 28. 

Leshchynska, I., Sytnyk, V., Morrow, J. S. and Schachner, M. Neural cell adhesion molecule (NCAM) association with PKCP2 via pi spectrin is implicated in NCAM-mediated neurite outgrowth. /. Cell Biol. 161 625-639, 2003. 

FIGURE 7-1 The immunoglobulin (Ig) gene family of molecules. Several varieties of Ig domain-containing molecules are contained within the Ig gene superfamily. Most are type I membrane proteins some have only Ig domains or other moieties that may convey function (see text). V, variable Ig domain C, constant Ig domain MAG, myelin-associated glycoprotein NCAM, neural cell adhesion molecule GPI, glycosylphosphatidyl-inositol EC, extracellular domain FN, fibronectin. 

FIGURE 7-6 Neural cell adhesion molecule (NCAM) carries different levels of polysialic acid. (A) NCAM is depicted on a growing axon, without polysialic acid. Under these conditions, NCAM and LI molecules interact homophilically and axons fasciculate. (B) NCAM carries polysialic acid (PSA), and NCAM and LI molecules are far apart and cannot, therefore, interact. Growing axons do not fasciculate under these circumstances. 

Walsh, F. S. and Doherty, P. Neural cell adhesion molecules of the immunoglobulin superfamily role in axon growth and guidance. Annu. Rev. Cell. Dev. Biol. 13 425-456, 1997. 

Adhesion molecules such as LI, neural cell adhesion molecule (N-CAM) and N-cadherin promote axonal regeneration by homophilic interactions between axons and Schwann cell surfaces (see Ch. 7). The expression of p75 (low affinity NGF receptor, Ch. 27) is also increased at the Schwann cell surface after injury. Extracellular matrix molecules, such as tenascin and proteoglycans, increase the regenerative potential of damaged peripheral nerves by binding to integrins on the axonal surface. 

LTX latrotoxins NCAM neural cell adhesion molecule... 

Schellinck, H. M., Arnold, A., Rafuse, V. (2004) Neural Cell Adhesion Molecule (NCAM) null mice do not show a deficit in odor discrimination learning. Behav. Brain Res.152, 327-334. 

Human colon (71), swine trachea (93), and rat sublingual mucins (34), in addition to N-linked chains Glycophorin (84), neural cell adhesion molecule (NCAM) (94)... 

AC VIII, adenylyl cyclase type VIII BDNF, brain-derived neurotrophic factor CamKII, calcium-calmodulin kinase II GIRK2, G protein-activated inward rectifying potassium 2 MAOA, monoamine oxidase A n.d., not determined NCAM, neural cell adhesion molecule nNOS, neuronal nitric oxide synthase Petl, ETS domain transcription factor tPA, serine protease tissue-plasminogen activator (tPA). t/ > Increase/decrease in anxiety-related behavior. No effect. 

C. Zuber, P. M. Lackie, W. A. Cattarall, and J. Roth, Polysialic acid is associated with sodium channels and the neural cell adhesion molecule N-CAN in adult rat brain, J. Biol. Chem. 267 9965 (1992). 

R. D. McCoy, E. R. Vimr, and F. A. Troy, CMP-NeuNAc poly-a-2,8-sialosyl sialyltransferase and the biosynthesis of poiysialosyl units in neural cell adhesion molecules, J. Biol. Chem. 260 i 2695 (1985). 

E2. Ely, S. A., and Knowles, D. M., Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am. J. Pathol. 160, 1293—1299 (2002). 

NCAM (neural cell adhesion molecule) good marker for NK cells 9-O-acetyl GD3 surface ganglioside involved in receptor complexes during cell signaling... 

Honer WG, Falkai P, Young C, Wang T, Xie J, et al. 1997. Cingulate cortex synaptic terminal proteins and neural cell adhesion molecule in schizophrenia. Neuroscience 78 99-110. 

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