Neuron-glia cell adhesion molecule

Well-studied CAMs of the Ig-family in the nervous system are the neural cell adhesion molecule (N-CAM) and the neuron-glia cell adhesion molecule (LI or NILE). Both molecules are found on neurons and have been suggested to mediate neuron-glia interactions by heterophilic binding mechanisms. Currently, it is unknown whether astroglia express N-CAM and/or LI in vivo (Persohn and Schachner, 1987 Bartsch et al.,... 

MYELIN FORMATION, STRUCTURE AND BIOCHEMISTRY 51 MEMBRANE TRANSPORT 73 ELECTRICAL EXCITABILITY AND ION CHANNELS 95 CELL ADHESION MOLECULES 111 THE CYTOSKELETON OF NEURONS AND GLIA 123... 

L., Margolis, R.K., Grumet, M. and Margolis, R.U. (1994) Interactions of the chondroitin sulfate proteoglycan phosphacan, the extracellular domain of a receptor-type protein tyrosin phosphatase, with neurons, glia, and neural cell adhesion molecules. J. Cell Biol. 127 1703-1715. 

Neuron-glial adhesion in nerve cell cultures is mediated by the pi subunit AMOG (adhesion molecule on glia) in the aipi isozyme of Na,K-ATPase [51]. Antibodies to the pi subunit dissociate cell-cell associations and also increase the rate of active... 

Other putative laminin-binding proteins have been described from a number of sources (for example, Smalheiser and Schwartz, 1987). Kleinman et al. (1991) used a synthetic peptide derived from the a chain of laminin to elute a 110 kDa protein from brain tissue however, the resulting molecule had sequence similarity to nucleolin. This putative receptor appears to be expressed in postnatal brain, particularly the hippocampus (Luckinbilledds et al., 1995). Albini et al. (1992) have described the isolation of a similar 100 kDa molecule from Y-79 retinoblastoma cells that is eluted from laminin affinity columns by 20 mM EDTA this binding protein has only intermediate affinity for laminin, however, but may act to influence gene expression independent of attachment. Laminin has been reported to bind to Ng-CAM on the basis of antibody inhibition studies, an interaction important for the formation of neuron-glia adhesion (Grumet etal., 1993). 

Antonicek, H., Persohn, E. and Schachner, M. (1987) Biochemical and functional characterization of a novel neuron-glia adhesion molecule that is involved in neuronal migration./ Cell Biol. 104 1587-1595. 

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