Expression domains

Cadherins are a superfamily of Ca2+-sensitive cell-cell adhesion molecules, which cause homophilic cell interactions. Cadherins can be divided into different subfamilies, namely, classical cadherins, desmosomal cadherins, protocadherins, and nonconventional cadherins (7TM cadherins, T-cadherin, FAT). Classical cadherins are often denoted by a prefix reflecting their principal expression domains e.g., E is epithelial, N is neuronal, and P is placental. However, this classification is not stringent, as for instance E-cadherin can also be found in certain neuronal tissues, and N-cadherin is also found in epithelial cells. Among the desmosomal cadherins, two subfamilies can be distinguished the desmocollins 1-3 and the desmogleins 1-4. 

Simeone, A., Acampora, D., Gulisano, M., Stornaiuolo, A., and Bon-cinelli, E (1992) Nested expression domains of four homeobox genes in developing rostral brain. Nature 358 687-690. 

C. Meno, Y. Ito, Y. Saijoh, Y. Matsuda, K. Ikshiro, S. Kuhara, and H. Hamada. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2, their distinct expression domains, chromosomal linkage and direct neuraiizing activity in Xenopus embryos. Cell, 82 (5), 803-814, 1995. 

Fish OR genes are expressed in spatial expression domains that are broader and overlap more than the mammalian expression zones, but otherwise have the same characteristics of several receptors intermingling in one domain (Weth et al. 1996). 

Weth F, Nadler W, Korsching S (1996) Nested expression domains for odorant receptors in zebrafish olfactory epithelium. Proc Natl Acad Sci USA 93 13321-13326 Yamagami S, Suzuki N (2005) Diverse forms of guanylyl cyclases in medaka fish - their genomic structure and phylogenetic relationships to those in vertebrates and invertebrates. Zoolog Sci 22 819-835... 

Nurmi EL, Amin T, Olson LM, Jacobs MM, McCauley JL, Lam AY, Organ EL, Folstein SE, Haines JL, Sutcliffe JS (2003b) Dense linkage disequilibrium mapping in the 15ql l-ql3 maternal expression domain yields evidence for association in autism. Mol Psychiatry 8 624-634, 570. 

Gaunt, S.J., Dean, W., Sang, H., Burton, R.D. 1999. Evidence that Hoxa expression domains are evolutionarily transposed in spinal ganglia, and are established by forward spreading in paraxial mesoderm. Mech. Dev. 82, 109-118. 

Subramanian, V., Meyer, B.I., Gruss, P. 1995. Disruption of the murine homeobox gene Cdxl affects axial skeletal identities by altering the mesodermal expression domains of Hox genes. Cell 83, 641-653. 

Robinson, G.W., Mahon, K.A. 1994. Differential and overlapping expression domains of Dlx-2 and Dlx-3 suggest distinct roles for Distal-less homeobox genes in craniofacial development. Mech. Dev. 48, 199-215. 

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