Neisseria gonorrhoeae infection

Newhall, J., Sawyer, W.D., and Haak, R.A. (1980) Cross-linking analysis of the outer membrane proteins of Neisseria gonorrhoeae. Infect. Immun. 28, 785-791. 

Zenni MK, Giardina PC, Harvey HA, et al. Macropinocytosis as a mechanism of entry into primary human urethral epithelial cells by Neisseria gonorrhoeae. Infect Immiin 2000 68(3) 1696-1699. 

Hitchcock, PJ. Analyses of gonococcal lipopolysaccharide in whole-cell lysates by sodium dode-cyl sulfate-polyacrylamide gel electrophoresis stable association of lipopolysaccharide with the major outer membrane protein (protein I) of Neisseria gonorrhoeae. Infect Immun 46 (1984) 202-212. 

Johnson RE, Newhall WJ, Papp JR, Knapp JS, Black CM, Gift TL, et al. Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections—2002. MMWR Recomm Rep. 

Buimer M, Bruisten S. Comparison between the LCx Probe system and the COBAS AMPLICOR system for detection of Chlamydia trachomatis and Neisseria gonorrhoeae infections in patients attending a clinic for treatment of sexually transmitted diseases in Amsterdam, The Netherlands. J Clin Microbiol 2001 39 829-35. 

Chloroquine (Aralen) is also used in die treatment of extraintestinal amebiasis (see section on Amebicides). Doxycycline is also used to treat infections caused by Neisseria gonorrhoeae, Treponema pallidum, Listeria monocytogenes, Clostridium, and Bacillus anthracis when penicillin is contraindicated. Quinine also may be used for die prevention and treatment of nocturnal leg cramps. 

Hyperacute bacterial conjunctivitis is associated with gonococcal infections in sexually active patients. The causative agents are Neisseria gonorrhoeae or N. meningitidis. Prompt work-up and treatment is required, as corneal perforation occurs in 10% of cases within 48 hours.12 An ophthalmologist should complete a conjunctival scraping and susceptibility testing.10... 

Gonorrhea is a curable STI caused by the gram-negative diplococcus Neisseria gonorrhoeae. Proper therapeutic management with antimicrobial agents is essential to eradicate this infection and prevent the development of associated sequelae. 

Neisseria gonorrhoeae is a gram-negative diplococcus estimated to cause up to 600,000 infections per year in the United States. Humans are the only known host of this intracellular parasite. 

Clotrimazole is an imidazole antifungal agent indicated for the treatment of fungal infections caused by Candida albicans. The administration of clotrimazole would be of no use in the treatment of infections caused by Chlamydia trachomatis, Neisseria gonorrhoea, Staphylcoccus aureus and Streptococcus pneumoniae. 

Alternative therapy for the following infections when penicillin is contraindicated Uncomplicated gonorrhea due to Neisseria gonorrhoeae] syphilis due to Treponema pallidum, yaws due to T. pertenue] Listeria monocytogenes] anthrax due to Bacillus anthracis] Vincent s infection due to Fusobacterium fusiforme] actinomycosis due to Actinomyces sp. Clostridium sp. 

Acute salpingitis (pelvic inflammatory disease) due to Neisseria gonorrhoeae. Chlamydia trachomatis, or both is often complicated by superinfection with gramnegative bacilli and anaerobes. A combination of gentamicin, clindamycin, and doxycycline has been shown to be an effective treatment for this polymicrobial infection. 

Hedges, S.R., et al. 1998. Cytokine and antibody responses in women infected with Neisseria gonorrhoeae Effect of concomitant infections. J Infect Dis 178 742. 

Neisseria gonorrhoeae (gonococcus) Arthritis-dermatitis syndrome genital infections Ceftriaxone, cefixime, cefotaxime, or cefpodoxime. Ciprofloxacin or ofloxacin... 

T21. Tronca, E., Handsfield, H. H., Wiesner, P. J., and Holmes, K. K., Demonstration of Neisseria gonorrhoeae with fluorescent antibody in patients with disseminated infection. J. Infect. Dis. 129, 583-586 (1974). 

Dale, P.A. McQuillen, D.P., Gulati, S., Rice, P.A. Human vaccination with Escherichia coli 35 mutant induces cross-reactive bactericidal antibody against Neisseria gonorrhoeae lipooligosaccharide. J Infect Dis 166 (1992) 316. 

Neisseria gonorrhoeae and Neisseria meningitides are pathogenic for humans in which they cause gonorrhea and meningitis. Both of these organisms, which infect human mucosal surfaces, elaborate a highly... 

Sexually transmitted infections are a common cause of PID. The main organisms are Chlamydia trachomatis and Neisseria gonorrhoeae. 

Metronidazole is included to improve coverage for anaerobes as initial infection with Chlamydia or Neisseria gonorrhoea can cause epithelial damage, allowing other organisms to enter the cervix and cause ascending infection. 

Gram-negative cocci that cause infections include Neisseria gonorrhoeae, which causes gonorrhea. Aetoena gonorrhoeae initially causes hyperpurulent conjunctivitis but can quickly invade the cornea and the rest of the eye. 

Gram-negative Neisseria gonorrhoeae is within the spectrum of activity for penicillin G, but many strains of this organism produce penicillinase. Because antibiotic therapy is typically taken before bacterial susceptibilities are known, recommended drugs for treatment of gonococcal infections include the cephalosporins, ceftriaxone and cefixime, which are not inactivated by gonococcal penicillinase. 

Coexistent infection. Chlamydia trachomatis is frequently present with Neisseria gonorrhoeae tetracycline by mouth for 7 days or a single oral dose of azithromycin Ig will treat the chlamydial urethritis. 

For infections with Neisseria gonorrhoea, tetracyclines are not indicated, owing to the higher prevalence of... 

Stamm WE, Guinan ME, Johnson C, Starcher T, Hohnes KK, McCormack WM. Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. N Engl J Med 1984 310 545-9. 

The susceptibility of almost all strains of various species of Neisseria (gonorrhoeae, meningitidis, flava) to in vitro inhibition by acetazolamide (2-acetamino-l,3, thiadiazole-5-sulfonamide) is unique relative to other organisms,90 91 but apparently does not carry over to in vivo infections. Inhibition of only N. gon. occturred at high CO2 concentrations the other N. and resistant bacteria appear to have low concentrations of carbonic anhy-drase.90... 

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