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Imidazole antifungal agents

Miconazole is an imidazole antifungal agent used as miconazole base or miconazole nitrate for the treatment of superficial candidiasis and of skin infections dermato-phytosis and pityriasis versicolor. The drug has also been given intravenously by infusion for the treatment of disseminated fungal infections. Miconazole can be given by mouth in a dose of 120-240 mg, as oral gel four times daily after food, for... [Pg.5]

Clotrimazole is an imidazole antifungal agent indicated for the treatment of fungal infections caused by Candida albicans. The administration of clotrimazole would be of no use in the treatment of infections caused by Chlamydia trachomatis, Neisseria gonorrhoea, Staphylcoccus aureus and Streptococcus pneumoniae. [Pg.246]

Patients allergic to penicillin may be cross-sensitive to cephalosporins. Cephalosporins (cefaclor, first-generation cephalosporin) are therefore avoided in these patients and instead macrolides (for example, erythromycin) are generally administered. Ketoconazole is an imidazole antifungal agent. [Pg.293]

The use of imidazole antifungal agents such as econazole is the mainstay of treatment in vaginal thrush (candidiasis). [Pg.302]

Miconazole (Monistat) is a broad-spectrum imidazole antifungal agent used in the topical treatment of cutaneous dermatophyte infections and mucous membrane Candida infections, such as vaginitis. Minimal absorption occurs from skin or mucous membrane surfaces. Local irritation to skin and mucous membranes can occur with topical use headaches, urticaria, and abdominal cramping have been reported with treatment for vagiiutis. [Pg.600]

I Contraindications Hypersensitivity to tioconazole or other imidazole antifungal agents... [Pg.1222]

Flutamide Fluoxetine Imidazole antifungal agents (e.g., ketoconazole)... [Pg.7]

Hexane-2-PrOH-DEA 425 74 1 Imidazole antifungal agents Chiralcel OD, OJ, OB, OK, OC, and OF... [Pg.57]

Hexane-2-PrOH-DEA 400 99 1 Imidazole antifungal agents Chiralpak AD, AS, and AR... [Pg.59]

TABLE 5 Effects of Flow Rate and Substituents on Chiral Resolution of Imidazole Antifungal Agents on Amylose CSPs Using Hexane-2-Propanol-Diethylamine (400 99 1, v/v/v) as the Mobile Phase... [Pg.74]

Vukovich, R.A., A. Heald, and A. Darragh. 1977. Vaginal absorption of two imidazole antifungal agents, econazole and miconazole. Clin Pharmacol Therap 21 121. [Pg.439]

Concomitant use of macrolide antibiotics or imidazole antifungal agents may lead to serious ventricular arrhythmias. Fexofenadine ... [Pg.433]

Potent isoprenoid-containing imidazole antifungal agents, such as AFK-108 (l-[2-(2,4-dichlorophenyl)-2-( (2 )-3,7-dimethylocta-... [Pg.291]

If the displacement reaction is carried out between imidazole derivative and thiophene analogue the antifungal agent tiaconazole (40) results. A rather slight variant of... [Pg.133]

Nafimidone (93), an anticonvulsant compound, also contains an imidazole moiety It seems to have been discovered by accident during a search for antifungal agents Its synthesis is straightforward involving displacement with imidazole of the activated chlorine atom of chloro-methyl-p-naphthylketone (92) [32]... [Pg.90]

Bifonazole (109) is claimed to be remarkably non-toxic and is marketed as a topical antifungal agent overseas. It can be conveniently synthesized in the by now familiar way by reduction of p-phenylbenzophenone (108) with borohydride, conversion to the chloride with thionyl chloride, and then imidazole displacement to bifonazole (109) [39]. [Pg.93]

Fucicort contains fusidic acid (antibacterial) and betamethasone (corticosteroid), which is more potent than hydrocortisone (corticosteroid). Fucidin H contains fusidic acid and hydrocortisone Daktacort contains miconazole (imidazole antifungal) and hydrocortisone Canesten HC contains clotrimazole (imidazole antifungal) and hydrocortisone. Otosporin contains hydrocortisone in combination with two antibacterial agents, namely neomycin and polymyxin. [Pg.27]

The use of topical antifungal agents (imidazole antifungals and terbinafine) is the first-line of treatment in athlete s foot. Patients should be advised to be persistent in treatment and that application of the product should be continued for about 10 days after all traces have disappeared. This will ensure eradication. Patient should be educated on non-pharmacotherapeutic measures and adjunctive therapy that contribute towards the management of the condition. The area should be washed regularly and dried thoroughly as... [Pg.129]

Athlete s foot, tinea pedis, is a condition caused by a fungus. Management of athlete s foot lies with the use of antifungal preparations such as clotrimazole (an imidazole antifungal) and tolnaftate. Salicylic acid is a keratolytic agent indicated for use in treatment of corns, calluses and warts. [Pg.213]

If the displacement reaction is carried out between imidazole derivative and thiophene analogue the antifungal agent tiaconazole (40) results. A rather slight variant of this sequence produces antifungal sulconazole (41).Obvious variants of the route explicated above for ketoconazole (34) lead to parconazole (42)and doconazole (43),instead. [Pg.1182]

Pharmacology Ketoconazole, an imidazole broad-spectrum antifungal agent, impairs the synthesis of ergosterol, the main sterol of fungal cell membranes, allowing increased permeability and leakage of cellular components. Pharmacokinetics ... [Pg.1661]

Ketoconazole remains useful in the treatment of cutaneous and mucous membrane dermatophyte and yeast infections, but it has been replaced by the newer triazoles in the treatment of most serious Candida infections and disseminated mycoses. Ketoconazole is usually effective in the treatment of thrush, but fluconazole is superior to ketoconazole for refractory thrush. Widespread dermatophyte infections on skin surfaces can be treated easily with oral ketoconazole when the use of topical antifungal agents would be impractical. Treatment of vulvovaginal candidiasis with topical imidazoles is less expensive. [Pg.600]

The various agents, e.g. selenium sulfide and imidazole antifungals lotion or... [Pg.454]

See other pages where Imidazole antifungal agents is mentioned: [Pg.1362]    [Pg.47]    [Pg.170]    [Pg.3970]    [Pg.184]    [Pg.128]    [Pg.2425]    [Pg.562]    [Pg.1079]    [Pg.502]    [Pg.1362]    [Pg.47]    [Pg.170]    [Pg.3970]    [Pg.184]    [Pg.128]    [Pg.2425]    [Pg.562]    [Pg.1079]    [Pg.502]    [Pg.33]    [Pg.249]    [Pg.39]    [Pg.899]    [Pg.256]    [Pg.62]    [Pg.187]    [Pg.755]    [Pg.1181]    [Pg.1440]    [Pg.272]    [Pg.273]    [Pg.274]    [Pg.274]   
See also in sourсe #XX -- [ Pg.562 ]



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