Nausea nephritis

A chemical worker who accidentally swallowed Ig (about 140mg/kg) developed nausea, dizziness, headache, pain and irritation in the eyes, conjunctivitis, and toxic nephritis. He recovered completely after 2 weeks. ... 

Inhalation of high concentrations of the dust by one worker caused temporary coma followed by weakness, myalgia, anuria, and later polyuria. After ingestion of 2-5 g of picric acid, which has a bitter taste, there may be headache, vertigo, nausea, vomiting, diarrhea, yellow coloration of the skin, hematuria, and albuminuria high doses cause destruction of erythrocytes, hemorrhagic nephritis, and hepatitis. ... 

Adverse reactions may include the following Fever porphyria dysuria gout hepatic reaction nausea vomiting anorexia thrombocytopenia and sideroblastic anemia with erythroid hyperplasia vacuolation of erythrocytes increased serum iron concentration adverse effects on blood clotting mechanisms mild arthralgia and myalgia hypersensitivity reactions including rashes, urticaria, pruritus fever acne photosensitivity porphyria dysuria interstitial nephritis. 

Patients should be warned that rifampicin colors urine, tears and other body fluids reddish-orange. Adverse effects further include rashes and pruritus and gastrointestinal complaints like nausea, anorexia and diarrhoea. With intermittent therapy a probably allergic hypersensitivity reaction can occur which mostly manifests itself as a flu-like syndrome with fever but can also result in nephritis and acute tubular necrosis. Elevation of serum transaminase levels occur frequently but clinical hepatitis is rare. Fatal outcome has been reported however. 

Adverse effects. Nausea, anorexia, vomiting, skin rash, diarrhea, hypersensitivity reactions including to ordinary salicylates, rarely blood dyscrasias, pancreatitis, hepatitis, interstitial nephritis. 

Carmustine Same as above Brain cancer, Flodgkin s and non-Flodgkin s lymphoma Nausea and vomiting Myelosuppression rarely interstitial lung disease and interstitial nephritis... 

Crossover studies have shown that mesalazine has about a 10-fold lower potential than sulfasalazine for inducing allergic reactions or causing intolerance. Adverse effects with all aminosalicylates include (generally more frequent with sulfasalazine) headache, nausea, abdominal pain, dyspepsia, fatigue, rash, fever, rarely exacerbation of the disease, pancreatitis, pericarditis, pneumonitis, liver disease, nephritis, and bone marrow depression. Watery diarrhea is an adverse effect unique to olsalazine, while anorexia, folate malabsorption, hemolysis, neutropenia, agranulocytosis, male infertility, and neuropathy are unique to sulfasalazine. 

Mercury is an accumulative poison. Its toxicity depends on its form. Symptoms may start rapidly after acute exposure to high air concentrations of mercury vapor, and can include fever, chills, and nausea. In severe cases (e.g., as a consequence of heating), pulmonary edema may cause death within a few days. Acute exposure to mercury vapor can also produce bronchitis and interstitial pneumonitis. The toxicity of mercuric chloride (i.e., corrosive sublimate) has been well established. Oral ingestion causes severe abdominal cramps, possible ulceration and bleeding of the gastrointestinal tract, and a bloody diarrhea. Loose teeth are noted and hepatitis has been recorded. Nephritis is common if the renal tubes are extensively damaged, it could lead to a... 

When used in combination with corticosteroids, cyclophosphamide is dosed at 1-3 mg/kg for oral therapy and 0.5-1.0 g/m of body surface area for intravenous therapy. The most common route of cyclophosphamide administration is intravenous, although there is little evidence that this is better than oral administration. Likewise, there is no evidence to suggest the optimal duration of treatment. Based on empirical experience, cyclophosphamide generally is dosed monthly for 6 months and then every 3 months for a period of either 2 years or for 1 year after the nephritis is in remission." " Of course, cyclophosphamide therapy is not without risk. Serious toxic effects include suppression of hematopoiesis, opportunistic infections, bladder complications (e.g., hemorrhagic cystitis and cancer), sterility, and teratogenesis. White blood cell counts must be monitored during cyclophosphamide therapy, and if the nadir is less than 1500/mm, the dose must be adjusted to keep the white cell count above 1500/mm. Nausea and vomiting associated with cyclophosphamide can be controlled with oral ondansetron plus dexamethasone. ... 

ACUTE HEALTH RISKS irritation of eyes and skin irritation to mucous membranes and upper respiratory tract narcotic effects dizziness nausea vomiting drowsiness incoordination confusion abdominal pains hiccoughs visual disturbances delirium convulsions slurred speech staggering liver and kidney damage acute nephritis anemia coma death. 

Patients who take fluoroquinolones can, in rare cases, experience dizziness, drowsiness, restlessness, stomach distress, diarrhea, nausea and vomiting, psychosis, confusion, hallucinations, tremors, hypersensitivity, and interstitial nephritis (kidney). 

Picric acid is a highly toxic substance. Ingestion can cause severe poisoning in humans. The toxic symptoms are headache, nausea, vomiting, abdominal pain, and yellow coloration of the skin. High doses can cause destruction of erythrocytes, gastroenteritis, nephritis, hepatitis, and hematuria. Contact with the eyes can produce irritation and corneal injury. Skin contact with powder can result in sensitization dermatitis. The lethal dose (oral) in rabbits is 120 mg/kg. 

In summary, Cu therapy administered according to recommended doses was effective and did not as a rule cause untoward reactions. Onset of improvement was immediate, definite and progessive in most patients. Twelve patients were followed for over 2 yr and showed no relapse. It was felt that this period was long enough to make it unlikely that these were spontaneous remissions. Erythrocyte sedimentation rates returned to normal faster in patients with RA of less than 1 yr duration than in those with chronic disease. Fifty-one of 59 patients experienced no ill-effect attributable to the medication. Only minor side effects, such as malaise, nausea and slight albuminuria were noted in 8 patients. No signs of marrow depression were noted in these 8 patients. Copper compounds used to continue therapy in patients who were resistant or intolerant to Au therapy were found to be advantageous since they were used without ill-effects in the event of Au therapy-induced dermatitis (rashes or stomatitis) or nephritis (albuminuria). 

A 19-year-old man with ulcerative colitis was given cefprozil 1 g/day, mesalazine 3 g/day, methylprednisolone 32 mg/day, and ranitidine 300 m day. The cefprozil and ranitidine were withdrawn after 10 days and the methylprednisolone was tapered to zero over the next 3 months. The mesalazine was discontinued after 1 month because of vomiting and diarrhea. He was given sulfasalazine 2 g/day, but 7 months later developed fatigue, nausea, fever, and nocturia. He had raised serum urea and creatinine concentrations, and abdominal ultrasound showed normal kidneys. Sulfasalazine was withdrawn, but over the next 4 days, the serum urea and creatinine increased further and a renal biopsy showed changes compatible with granulomatous interstitial nephritis. Renal function recovered completely after a few days treatment with methylprednisolone. 

M.A. 16 years F Cirrhosis, pancreatitis, nephritis 35 Nausea,vomiting Not applicable Not applicable... 

Urinary tract A 69-year-old woman developed biopsy-proven acute granulomatous interstitial nephritis while on levetiracetam 1000 mg/day. She made a complete recovery after cessation of the levetiracetam [103 ]. A 45-year-old man similarly developed interstitial nephritis with intractable nausea and vomiting while taking levetiracetam for seizures in the setting of a low grade glioma. The medication was changed and his renal function rapidly improved to his baseline [104 ]. 

Kidney A 14-year-old boy with ulcerative colitis presented with progressive fatigue, nausea and abdominal pain for the past 2 weeks. His ulcerative colitis had been in remission while on mesalazine (1-5 g/day) for the past 3 years. A condition of renal failure was documented by elevations in serum creatinine, mea, potassium and phosphorus levels. Urine analysis showed 40/hpf leukocytes and proteinuria. Creatinine elevation slightly improved by large volume fluid infusion and correction of electrolyte distmbances. A renal biopsy showed active mononuclear infiltration with scattered eosinophils, consistent with interstitial nephritis. Mesalazine was discontinued and the patient was started on intravenous methylprednisolone (1 mg/kg/day) for 3 days followed by prednisone taper for 2 months. His symptoms improved and creatinine normalised within 8 weeks [87 + ]. 

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