Nanoparticles targeted delivery

H.L. Liu, et al., Magnetic resonance monitoring of focused ul-trasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain, Proc. Natl. Acad. Sci. U.S.A. 107 (34) (2010) 15205-15210. [Pg.386]

Tan J, Thomas A, Liu Y (2012) Infiuence of red blood cells on nanoparticle targeted delivery in microcirculation. Soft Matter 8(6) 1934-1946... [Pg.2359]

Dextran Nanoparticles Targeted delivery of cisplatin for breast cancer growth and metastasis [21]... [Pg.40]

Davis ME (2009) The first targeted delivery of siRNA in humans via a self-assembling, cyclodextrin polymer-based nanoparticle from concept to clinic. Mol Pharmaceutics 6 659-668... [Pg.30]

Recently, nanoparticle-aptamer bioconjugates, as shown in Fig. 9, have been developed and demonstrated for targeted delivery to cancer cells. The imaging... [Pg.244]

Shenoy DB, Amiji MA (2005) Poly(ethylene oxide)-modified poly(epsilon-caprolactone) nanoparticles for targeted delivery of tamoxifen in breast cancer. International Journal of... [Pg.264]

Devalapally H, Shenoy D, Little S, Langer R, Amiji M (2007) Polyethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of... [Pg.308]

As of today, there are no commercially available pharmaceutical products of this technology. The pharmaceutical industry however, is involved in developing nanoparticle-based delivery systems. Use of nanospheres to modify the blood-brain barrier (BBB)—limiting characteristics of the drug enables targeted brain delivery via BBB transporters and provides a sustained release in brain tissue and vaccine delivery systems to deliver therapeutic protein antigens into the potent immune cells are under investigation.103... [Pg.297]

Devalapally, H., Shenoy, D., Little, S., Langer, R., and Amiji, M. (2007), Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs Part 3. Therapeutic efficacy and safety studies in ovarian cancer xenograft model, Cancer Chemother. Pharmacol., 59(4), 477-484. [Pg.561]

Transferrin-containing CD polymer-based nanoparticles were studied as nucleic acid delivery system that can be modified for targeted delivery of small interfering ribonucleic acid (siRNA) to cancer cells. Molecular studies showed that the siRNA CD nanoparticles reduced levels of Ewing s transcript by 80% and inhibited growth of cultured Ewing s tumor cell line. It was also reported that this delivery system indicated a lack of toxicity [39],... [Pg.1232]

As described in papers using gold nanoshells that have also shown surface plasmon bands in the near-1R region [36, 37], the targeted delivery of nanoparticles allows us to... [Pg.393]

Pinto-Alphandary H, Andremont A, Couvreur P. Targeted delivery of antibiotics using liposomes and nanoparticles research and applications. Int J Antimicrob Agents 2000 13 155-168. [Pg.389]

As mentioned previously, the targeted delivery of suitable contrast agents for ultrasound or MRl imaging methodologies would be desirable for many applications. It remains to be seen whether microbubbles, magnetic nanoparticles or other active compounds can cross barriers in vivo (e.g., the endothehum) and can be delivered in sufficient amounts at sites of dis-... [Pg.1289]

Mitra S, Gaur U, Ghosh P C, et al. (2001). Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. J. Control. Rel. 74 317-323. [Pg.153]

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