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Nanoparticles targeted drug delivery

Liu Y, Shah S, Tan J (2012) Computational modeling of nanoparticle targeted drug delivery. Rev Nanosci Nanotechnol l(l) 66-83... [Pg.2359]

The concept of de-PEGylation can be applied to the development of nanoparticle-based drug delivery systems. PEG is used for the modification of liposomes to increase their blood circulation time [38], However, it also prevents cellular uptake, resulting in a decrease in therapeutic efficiency thus, modifications of the liposome surface with PEG interfere with membrane fusion to the cell membrane and liposome decomposition [39]. One of the possible strategies to solve this problem is to cleave the PEG chains after the nanoparticle reaches the target site (Fig. 9). This system of de-PEGylation of liposomes is also useful in avoiding the immune... [Pg.123]

Keywords Biocompatible Cancer diagnostics Functionalization Imaging Nanoparticles Surface modification Targeted drug delivery... [Pg.233]

Elucidation of intracellular trafficking and localization by means of CLSM is widely spread in the field of targeted drug delivery systems. Thus, CLSM analysis was performed to determine uptake and intracellular distribution of potential targeters [25, 43], drug conjugates [44, 45], as well as nanoparticles... [Pg.658]

Polymeric Nanoparticles. Polymeric nanoparticles are nanoscale aggregates of biocompatible or biodegradable polymers. The size of nanoparticles varies from 10 to 1000 nm, and obviously, particles with a size smaller than 200 nm are preferable for tumor-targeted drug delivery. [Pg.1335]

Keywords Drug delivery systems Targeted drug delivery Nanoparticles Nanobiotechnology Personalized medicine Routes of drug administration Drug delivery devices Controlled release Protein/peptide delivery Drug formulations... [Pg.1]

Hans, M. L. Lowman, A. M. Biodegradable nanoparticles for drug delivery and targeting. Curr. Opin. Solid State Mater. Sci. 2002, 6, 319-327. [Pg.209]

Emerich DF, Thanos CG. Targeted nanoparticle-based drug delivery and diagnosis. J Drag Target 2007 15 163-183. [Pg.387]

Cheng, J., Teply, B. A., Sherifi, I., Sung, J., Luther, G., Gu, F. X., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Langer, R., Farokhzad, O. C. (2007). Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 28, 869-876. [Pg.54]

Gold Nanoparticles for Targeted Drug Delivery in Cancer... [Pg.256]

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See also in sourсe #XX -- [ Pg.266 ]



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