Myc oncogene

Sun L., Fuselier J.A., Murphy W.A., Coy D.H. Antisense peptide nucleic acids conjugated to somatostatin analogs and targeted at the n-myc oncogene display enhanced cytotoxity to human neuroblastoma 1M.R.32 cells expressing somatostatin receptors. Peptides 2002 23 1557-1565. 

Tavassoli, M., and S. Shall. 1988. Transcription of the c-myc oncogene is altered in spontaneously immortalized rodent fibroblasts. Oncogene 2(4) 337 15. 

Little CD, Nau MM, Carney DN et al. Amplifieation and expression of the c-Myc oncogene in human lung cancer eell lines. Nature 1983 306 194-196. 

Richmond, R.E., DeAngelo, A.B. Daniel. F.B. (1992) Immunohistochemical detection of ras and myc oncogene expression in regenerating rat liver. Toxicol. Lett., 60, 119-129... 

Similar studies have shown that the H-ras and the myc oncogenes can cooperate to produce dense foci of morphologically transformed cells from REF cultures (fig. S4.8). Thus, two cellularly derived oncogenes have been shown to complement each other to produce a fully transformed phenotype. Parallel experiments have been done on whole mice to show that the combination of ras and myc is highly tu-morigenic. Experiments of this sort suggest that at a mini-... 

Retinoids in Cancer Prevention and Treatment Since the discovery of vitamin A, the observation that the main effects of deficiency are hyperplasia and loss of differentiation of squamous epithelium has raised speculation that the vitamin may he associated with carcinogenesis. Either deficiency may be a risk factor for cancer or increased intake may be protective. Deficient animals develop more spontaneous tumors and are more sensitive to chemical carcinogens, whereas liver reserves of vitamin A are lower in patients with cancer than in controls. One of the genes repressed by retinoic acid is the myc-oncogene. 

Oshimura M, Gilmer TM, and Barrett JC (1985) Nonrandom loss of chromosome 15 in Syrian hamster tumours induced by v-Ha-ras plus v-myc oncogenes. Nature 316(6029) 636-639. 

Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, et al. 1995. An amino-terminal domain of Mxil mediates anti-myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80 777-86... 

Bartlett PF, Reid HH, Bailey KA, Bernard O (1988) Immortalization of mouse neural precursor cells by the c-myc oncogene. Proc Natl Acad Sci U S A 85 3255-3259... 

The answer is c. (Murray, pp 746-751. Scriver, pp 3-45. Sack, pp 245-257. Wilson, pp 151-180.) This case is an example of Burkitt s lymphoma, which may affect the tonsils or other lymphoid tissues. The translocation places the myc oncogene on chromosome 8 downstream of the very active heavy chain locus on chromosome 14, activating myc gene... 

Embryonic tumors (T4) that arise in the fetus or in young children frequently show a mixed population of differentiated and undifferentiated cells. This evidence suggests that the tumors may result from developmental disturbances during organogenesis that cause arrest of an early stage in the normal differentiation process to adult tissue. Enhanced expression of the N-myc oncogene has been... 

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