Mutagens mutagenesis

Ashby J. 1986. The prospects for a simplified and internationally harmonized approach to the detection of possible human carcinogens and mutagens. Mutagenesis 1 3-16. 

Sources Most of the data for this table were collected through a systematic search of announcements and news items in key journals, newsletters, and annual reports, Monographs were located by searching the WorldCat electronic database (keywords mutagens, mutagenesis). A smaller proportion of the data was collected at random, as I came across relevant information in the normal course of historical research. Although all source documents are in my possession, I have not listed them here individually. 

Zeiger E, Ashby J, Bakale G, Enslein K, Klopman G, Rosenkranz FIS. Prediction of Salmonella mutagenicity. Mutagenesis 1996 Sep ll(5) 471-84. 

Cariello NF, Wilson JD, Britt BH, Wedd DJ, Burlinson B, Gombar V. Comparison of the computer programs DEREK and TOPKAT to predict bacterial mutagenicity. Mutagenesis 2002 17(4) 321-9. 

Dean, S. W., Brooks, T. M., Burlinson, B., Mirsalis, J., Myhr, B., Recio, L., and Thybaud, V. (1999). Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens. Mutagenesis 14, 141-151. 

Fig. 9. Mutagenesis by a synthetic oligonucleotide of a cloned sequence available in single-stranded form (a) single-stranded M13 template containing uracil (U) residues (b) double-stranded product, uracil residues are not mutagenic (c) strong selection for M13 phages containing mutation of interest (23).

A scientifically evaluated and fully referenced data bank, developed and maintained by the National Cancer Institute (NCI). It contains some 8,000 chemical records with carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition test results. Data are derived from studies cited in primaiy journals, current awareness tools, NCI reports, and other special sources. Test results have been reviewed by experts in carcinogenesis and mutagenesis. 

The Ames test involves the reversion from a his— to his+ phenotype in any one of multiple bacterial strains (usually five strains are tested simultaneously). If the addition of test compound to a his— strain of bacteria allows them to grow on histidine deficient media, the obvious conclusion is compound-induced mutagenesis and a high potential hazard for the compound being carcinogenic. This test can also be conducted in the presence or absence of metabolic activation, in order to provide more information on potential risks (i.e., the parent compound may not be mutagenic, but the primary metabolite may present a safety risk). In practice, a positive Ames test almost always leads to discontinuing work on a compound of interest, and so these data are always collected prior to nomination of a compound for development. 

Schrader T J, Cherry W, Soper K, Langlois I and Vijay H M (2001), Examination of Altemaria altemata mutagenicity and effects of nitrosylation using the Ames Salmonella Test , Teratogenesis, Carcinogenesis, and Mutagenesis, 21, 261-274. 

TurboFP was also used as a basis for far-red fluorescent proteins (fRFPs). Residues surrounding the chromophore were mutagenized to create a library, which was subsequently subjected to random mutagenesis. A bright far-red variant with excitation and emission maxima at 588 and 635 nm, respectively was isolated and named Katushka [79]. This fast-maturing protein has an... 

Rosenkranz HS, Klopman G (1990) Structural basis of the mutagenicity of 1-amino-2-naphthol-based azo dyes. Mutagenesis 5(2) 137-146... 

Deknudt, G., A. Leonard, J. Arany, G.J. Du Buisson, and E. Delavignette. 1986. In vivo studies in male mice on the mutagenic effects of inorganic arsenic. Mutagenesis 1 33-34. 

Their direct mutagenicity makes them excellent vehicles for investigating mechanisms of mutagenesis and structural influences upon the mutagenic process and we have utilised many analogues as probes for drug-DNA interactions.46,49,50... 

Roldan-Aijona T, Garcia-Pedrajas MD, Luque-Romero FL, et al. 1991. An association between mutagenicity in rodents for 16 halogenated aliphatic hydrocarbons. Mutagenesis 6 199-205. 

Many plasmids are known to possess three properties (1) increased resistance to the bactericidal effects of UV and chemical mutagens, (2) increased spontaneous mutagenesis, and (3) increased susceptibility to UV and chemically induced mutagenesis. Some plasmids possess all three properties others may possess just one, for example, increased susceptibility to mutagenesis (review Mortelmans and Dousman, 1986). Often the profile of activity depends on the DNA repair status of the host cell (Pinney, 1980). Plasmid pKMIOl carries DNA repair genes and has been widely used in strains used in bacterial mutagenicity tests. 

Arlett, C.E and Cole, J. (1990). The third United Kingdom Environmental Mutagen Society collaborative trial overview, a summary and assessment. Mutagenesis 5 (Suppl.) 85-88. 

Clive, D. (1987). Historical overview of the mouse lymphoma TK+/, mutagenicity assay. In Mammalian Cell Mutagenesis, (Moore, M.M., Demarini, D.M., De Serres, F.J. and Tindall, K.R., Eds.). Banbury Report 28. Cold Spring Harbor Laboratory, NY, pp. 25-36. 

Yanofsky, C. (1971). Mutagenesis studies with Escherichia coli mutants with known amino acid and base-pair) changes. In Chemical Mutagens, Principles and Methods for Their Detection (Hollaender A., Ed.). Vol. 1, Plenum Press, New York, pp. 283-287. 

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