Cysteine proteinases inhibitors

Lustigman, S., Brotman, B., Huima, T., Prince, A.M. and McKerrow, J.H. (1992) Molecular-cloning and characterization of onchocystatin, a cysteine proteinase-inhibitor of Onchocerca volvulus. Journal of Biological Chemistry 267, 17339-17346. 

K. V., and Sloane, B. F., Cathepsin B to cysteine proteinase inhibitor balance in metastatic cell subpopulations isolated from murine tumors. Cancer Res. 50, 6278-6284 (1990). 

Sever, N., Filipic, M., Brzin, J., Lah, T. T. (2002). Effect of cysteine proteinase inhibitors on murine B16 melanoma cell invasion in vitro. Biol. Chem., 383, 839-842. 

Serine Proteinase Inhibitor I Serine Proteinase Inhibitor II Cysteine Proteinase Inhibitor Aspartic Proteinase Inhibitor Polyphenol Oxidase... 

Kidric, M., Fabian, H., Brzin, J., Popovic, T., and Pain, R.H. 2002. Folding, stability, and secondary structure of a new dimeric cysteine proteinase inhibitor. Biochem. Biophys. Res. Commun. 297 962-967. 

PLAT Plasminogen activator, tissue serine (or cysteine) proteinase inhibitor, Clade E (nexin, plasminogen activator inhibitor type 1), member 1... 

Finally, an article by Grubb should be mentioned in winch he stated that the use of cysteine proteinase inhibitors, such as cystatin C and kininogeus, could possibly reduce me risk of neurological complications such as cerebral hemorrhages [114]. 

A family of cysteine proteinase inhibitors different from the cystatin super-family was Isolated from pineapple stem acetone powder. These inhibitors have a Mr of about 5800 and are composed of a longer (41 amino acids) and a shorter (1L ammo acids) peptide chain connected with disulfide bonds [29]. The conserved sequence Gin- fal-Val-AJa-Gly of the cystatins is not present in these inhibitors, indicating a different mechanism of interaction. The bromelain inhibitor VI was found to share similar folding and disulfide band connectivities with the Bowman-Bilk trypsiu/chymatrypsm inhibitor from soybean [30,31]. Hie physiological role of these inhibitors remains undear. 

A potent cysteine proteinase inhibitor PCPl 8.3 was isolated from potato tubers. The inhibitor has a broad inhibitor spectrum, including the bromelain enzymes, which am not inhibited by cystatin. PCPI shows a Ki value of 190 nM for stem bromelain, 33 nM for firuit bromelain, 0.06 nM for ananain, and 3.3 nM for papain [78]. ft is proposed (hat the differences of inhibitory spectrum between PCPl and the cystatins may be those of distinct supeifamilies of cysteine proteinase inhibitors. 

A.J.Barrett, N. D. Rawlings,N. D. Davies, W. Machfcidt, G. Salvesen,and V.Tuik. Cysteine proteinase inhibitors of the cystatin luperiamily. In Proteinase Inhibitors (A. J. Barrett and G. Salvesen, eds.), Noith-Holland, Amsterdam. 19861, p. 515. 

Abe, K., Emori, Y., Kondo, H., Suzuki, K., and Arai, S. 1987. Molecular cloning of a cysteine proteinase inhibitor of rice (oryzacystatin). Homology with animal cysta-tins and transient expression in the ripening process of rice seeds. J Biol Chem 262 16793-16797. 

Nagata, K., Kudo, N., Abe, K., Arai, S., and Tanokura, M. 2000. Three-dimensional solution structure of oryzacystatin-I, a cysteine proteinase inhibitor of the rice, Oryza sativa L. japonica. Biochemistry 39 14753-14760. 

Synonyms cystatin A (R7) Acid cysteine proteinase inhibitor, epidermal SH-proteinase inhibitor, Stefin A cystatin B (R6) neutral cysteine proteinase inhibitor, Stefin B cystatin C See Section 8 in main text cystatin E cystatin M (S10) cystatin F leukocystatin (H2) cystatins S, SA, and SN (12) salivary cysteine proteinase inhibitor cystatin SN cystatin SU (Al) (Grubb, A., unpublished results) LMW- and HMW-kininogens (M9) a-cysteine proteinase inhibitor, a-thiol proteinase inhibitor. 

Al. Abrahamson, M., Barrett, A. J., Salvesen, G., and Grubb, A., Isolation of six cysteine proteinase inhibitors from human urine. Their physicochemical and enzyme kinetic properties and concentrations in biological fluids. J. Biol. Chem. 261(24), 11282—11289 (1986). 

A3. Abrahamson, M., Grubb, A., Olafsson, I., and Lundwall, A., Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin... 

A8. Abrahamson, M., Ritonja, A., Brown, M. A., Grubb, A., Machleidt, W., and Barrett, A. I., Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J. Biol. Chem. 262(20), 9688—9694 (1987). 

B3. Barrett, A. J., Fritz, H., Grubb, A., Isemura, S., Farvinen, M., el al., Nomenclature and classification of the proteins homologous with the cysteine-proteinase inhibitor chicken cystatin [letter]. Biochem. J. 236(1), 312 (1986). 

H3. Hall, A., Abrahamson, M., Grubb, A., Trojnar, J., Kania, P., et al., Cystatin C based peptidyl diazomethanes as cysteine proteinase inhibitors Influence of the peptidyl chain length. J. Enzyme Inhib. 6(2), 113-123 (1992). 

L5. Lerner, U. H., and Grubb, A., Human cystatin C, a cysteine proteinase inhibitor, inhibits bone resorption in vitro stimulated by parathyroid hormone and parathyroid hormone-related peptide of malignancy. J. Bone Miner. Res. 7(4), 433—440 (1992). 

N3. Ni, J., Abrahamson, M., Zhang, M., Fernandez, MA., Grubb A., et al., Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. J. Biol. Chem. 272(16) 10853-10858 (1997). 

S10. Sotiropoulou, G., Anisowicz, A., and Sager, R., Identification, cloning, and characterization of cystatin M, a novel cysteine proteinase inhibitor, down-regulated in breast cancer. J. Biol. Chem. 272(2), 903-910 (1997). 

T8. Tsushima, H., Mine, H., Hoshika, K., Kawakami, Y., Hyodoh, F., and Ueki, A., Candida albicans produces a cystatin-type cysteine proteinase inhibitor. J. Bacteriol. 174(14), 4807-4810. (1992). 

Hof, W., Biankenvoorde, M feerman, E., and Amerongen, A. (1997). The salivary lipocal-cin Von Ebner s gland protein is a cysteine proteinase inhibitor. J. Biol. Chem. 272, 1837-1841. 

Cystatin C is an endogenous cysteine proteinase inhibitor with practically the same Mr (13,300) as... 

Benjakul, S., Visessanguan, W., and An, H., Properties of cysteine proteinase inhibitors from black gram and rice bean, J. Food Biochem., 25, 211, 2001a. 

A. D. Gounaris, M. A. Brown, and A. J. Barrett. Human plasma alpha-cysteine proteinase inhibitor. Purification by affinity chromatography, characterization and isolation of an active fragment. Biochem. J. 221 445 (1984). 

Table 3.2. SERINE AND CYSTEINE PROTEINASE INHIBITOR LIBRARIES... 

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