Munro studies

Arranz MJ, Munro J, Sham P, Kirov G, Murray RM, Collier DA et al. Metaanalysis of studies on genetic variation in 5-HT2A receptors and clozapine response. Schizophr Res 1998 32(2) 93-99. 

Bates TE, S.M., Keeian J, Davey GP, Munro PM, Ciark JB. Inhibition of N-acetylaspartate production implications for 1H MRS studies in vivo. Neuroreport 1996 7 1397-1400. 

Lee, H.A. 1968. An Ontario kimberlite occurrence discovered by application of the glaciofocus method to a study of the Munro Esker. Geological Survey of Canada, Paper 68-7. 

Munro AM, Plante IJL, Ng MS, Ginger DS (2007) Quantitative study of the effects of surface ligand concentration on CdSe nanocrystal photoluminescence. J Phys Chem C 111 6220-6227... 

In India some of the early work was toward refinement of spraying to control leaf rust and the researchers started their studies with strong Bordeaux sprays. Munro and Sandararaman showed (46) that uncontrolled leaf disease reduced the coffee harvest very seriously, but that although 10-10-50 Bordeaux materially controlled the disease it depressed the fruit crop. With Bordeaux of formulas 5-5-50 or 2 -2 -50, the crop increase was one half to one third more than that produced under 10-10-50 Bordeaux or under no spray. 

Toxic effects are evident from stronger formulas of Bordeaux in other data reported by Munro and Sandararaman (46). Jones reported results from 5 years of study (30), from which it was evident that among the copper sprays at 1, 2.5, and 4% concentrations, the 2.5 was better than the others. The higher concentration reduced production. Spray studies in Costa Rica have given the author a chance (94y 100) to make observations on symptoms of copper toxicity all the copper sprays are, to a certain extent, toxic to coffee. 

The FDA allows single-dose human studies based on single-dose animal studies. A rodent and non-rodent species are required and signs of major toxicity must be demonstrated. The study design is outlined in the publication by Munro and Mehta and requires an observation period of 14 days after dosing. 

Munro A, Mehta D. Are single-dose toxicology studies in animals adequate to support single doses of new drug in humans Clin Pharmacol Ther 1996 59 258-64. 

Munro, A. W., et al. (1994) Resonance Raman spectroscopic studies on intact cytohrome P450-BM3. Biochem. Soc. Trans. 22, 54. 

Munro and colleagues evaluated 54 trials including those prior to 1965 (71). Two trials included were specifically for maxillary sinus carcinoma and nasopharyngeal carcinoma. Additionally, the Veteran s Laryngeal Cancer study with the end-point being organ preservation was also included. In this study, the overall benefit of adding chemotherapy was 6.5% (3.7% for induction, 12.1% for concomitant, adjuvant chemotherapy was not assessed). 

Polymer electrodes modified with pendant metal-bipyridyl groups have been studied in detail Eaves, J. G. Munro, H. S. Parker, D. Inorg. Chem. 1987,26,644 and references therein. 

S. M. Han and A. Munro, Transfer from manual to automated sample preparation a case study, J. Pharm. Biomed. Anal., 20, 785, 1999. 

Tavadia, S., Mortimer, E., and Munro, C. S., 2002, Genetic epidemiology of Darier s disease a population study in the west of Scotland. Br J Dermatol, 146 107-9. 

Millward MJ, Cantwell BM, Munro NC, et al. Oral verapamil with chemotherapy for advanced non-small cell lung cancer a randomised study. Br J Cancer 1993 67 (5) 1031—1035. 

Another amphetamine derivative, phentermine, has been in use as an appetite suppressant since its approval by the FDA in 1959. However, there are fewer clinical studies of phentermine s effectiveness in weight loss programs. Munro and colleagues (31) studied the effectiveness of phentermine during a 36-wk trial and reported a 13% reduction in initial body weight, compared to a 5.2% reduction for the placebo. The weight loss induced by phentermine over and above caloric restriction is comparable to that attained with fenfluramine. 

Two techniques, phase and pulse fluorometry, are used for the direct measurement of fluorescence decay rates, and their principles are described by Birks and Munro (1967), Parker (1968), and Birks (1970). The photon sampling method has proved useful and versatile. This is an iterative technique in which single photons are counted as a function of the time at which they appear after excitation and a complete decay curve is built up. (For recent references see e.g. Zimmerman et al., 1973, 1974). Wider use of the photon sampling technique will increase the precision of lifetimes obtained and extend the range of compounds studied to those with shorter lifetimes or very low fluorescence yields. 

If no direct measurement of the fluorescence lifetime is available the relations between the radiative lifetime and the fluorescence and absorption spectra can be used in conjunction with the quantum yield to obtain an indication of the fluorescence lifetime. Birks and Munro (1967) have reviewed the methods of calculating the radiative lifetime. In general these methods are limited to specific groups of compounds. For example, Favaro et al. (1973) applied Stickler and Berg s (1962) formula to the spectral data obtained from an excited state acid-base study of some styrylpyridines and found a lack of quantitative agreement between the measured and calculated lifetimes. 

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