Mouse macrophages, effect

Few studies have been conducted to date evaluating the effects of Pb exposure on host resistance to parasitic diseases, although one study examined the effect of Pb on the ability of mouse macrophages to kill Leishmania enriettii parasites in vitro [87], The authors found that 30-100 pM Pb acetate interfered with the killing ability of macrophages without producing macrophage cytotoxicity. 

Mercuric chloride can reduce the superoxide anion production by mouse macrophages [ 174], but this effect is probably of little toxicological significance in view of the high concentrations required and of its reversibilities. The effect has been suggested to result from loss of the reducing properties of cellular NADPH. 

I Namatame, H Tomoda, M Arai, S Omura. Effect of fungal metabolites cytochala-sans on lipid droplet formation in mouse macrophages. J Antibiot 53 12-18, 2000. 

Cocaine, like A -THC and morphine, has been reported to decrease the anti microbial acdvity of alveolar macrophages obtained from chronic crack cocaine smokers (Roth et al., 2004) and to decrease parameters of mouse macrophage acdvadon (Ou et al., 1989 Pacifici et al., 1993). However, in contrast to the effects of opioids, cocaine has been shown to increase the acdvadon of PMNs in human subjects, as evidenced by increased killing of Staphylococcus aureus (Baldwin et al., 1997). 

Oleuropein, dose dependently (1-100 pM) enhanced nitric oxide production in E. Coli lipopolysaccharide (LPS)-challenged mouse macrophages. The effect was mediated by stimulated expression of inducible NOS, determined by western blot analysis. No sign of macrophage cytotoxicity was observed with 100 pM oleuropein, which... 

All isoflavones [daidzein (27), genistein (28)] and isoflavanones (17, 86-93) did not stimulate nitric oxide production by mouse macrophage-like Raw 264.7 cells, but almost completely inhibited NO production by the lipopolysaccharide (LPS)-activated Raw 264.7 cells. ESR spectroscopy showed that secundifloran (88) and secundiflorol D (90), which showed the most inhibitory effect for NO production, efficiently scavenged the superoxide anion and NO radicals. From these results, it is suggested that the inhibition of macrophage NO production by these isoflavanones might, at least in part, be explained by their radical scavenging or reduction activity (Fig. 17) (Tables 3, 4) [16]. 

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