Microfluidic devices, surface

Surface Wettability of Materials Used for Microfluidic Device Surfaces... 

Proteins such as antibodies and enzymes can be deliberately anchored on microfluidic device surfaces by covalent bonds or molecular recognition in order to fabricate array biosensors. Nraispecific adsorption is the (usually) undesirable adsorption of molecules on the surface, and it ends up with... 

Biomolecular Adsorption in Microfluidics, Table 1 Advancing and static water contact angles on common materials used for microfluidic device surfaces [5,6, 18-41]... 

Surface treatments and surface interactions are the challenges ahead for the research community in relation to the development of advanced, sophisticated microfluidic devices. Surface modiflcation techniques need to be optimized for various applications, and particularly for disposable microfluidic devices. PDMS will be a popular material for future microfluidic devices, and some issues associated with most of the currently employed treatments, such as the hydrophobic recovery of PDMS surfaces, need to be adequately addressed. 

Keywords Polydimethylsiloxane (PDMS), microfluidic devices, surface modification, physical adsorption, inner migration, high... 

Hu SW, Ren X, Bachman M, Sims CE, Li GP, Allbritton NL (2002) Surface modification of poly(dimethylsiloxane) microfluidic devices by ultraviolet polymer grafting. Anal Chem 74 4117 Hunter RJ (1981) Zeta potential in colloid science. Academic Press, London Jensen KF (2001) Microreaction engineering is small better Chem Eng Sci 56 293... 

CE chips are mainly obtained using various glass substrates, from inexpensive soda-lime glass to high-quality quartz.Various polymer materials are also used. The choice of a particular material depends on its surface properties, ease of fabrication, which can be quite different according to the material origin, disposability, and price. Microfabrication processes were recently reviewed and the reader is thus referred to dedicated literature for additional useful information on microfluidic device fabrication. ... 

The use of a focused infrared laser beam on a surface results in local heating, which has been applied to synthesize MIPs locally by thermal polymerization [72]. In this case, a common thermo-initiator, azobisisobutyronitrile, was used together with a standard MIP recipe, to generate MIP microdots in a microfluidic device. 

Microfluidics and miniaturization hold great promise in terms of sample throughput advantages [100]. Miniaturization of analytical processes into microchip platforms designed for micro total analytical systems (/i-TASs) is a new and rapidly developing field. For SPE, Yu et al. [123] developed a microfabricated analytical microchip device that uses a porous monolith sorbent with two different surface chemistries. The monolithic porous polymer was prepared by in situ photoinitiated polymerization within the channels of the microfluidic device and used for on-chip SPE. The sorbent was prepared to have both hydrophobic and ionizable surface chemistries. Use of the device for sorption and desorption of various analytes was demonstrated [123]. 

Lahann, J., Balcells, M., Lu, H., Rodon, T., Jensen, K.F., Langer, R., Reactive polymer coatings A first step toward surface engineering of microfluidic devices. Anal. Chem. 2003, 75, 2117-2122. 

Weiller, B.H., Ceriotti, L., Shibata, T., Rein, D., Roberts, M.A., Lichtenberg, J., German, J.B., de Rooij, N.F., Verpoorte, E., Analysis of lipoproteins by capillary zone electrophoresis in microfluidic devices Assay development and surface roughness measurements. Anal. Chem. 2002, 74(7), 1702-1711. 

Walker, G.M., Piston, D.W., McGuinness, P.O., Rocheleau, J.V., A microfluidic device for partical surface treatment of islets of Langerhans. Micro Total Analysis Systems 2003, Proceedings 7th pTAS Symposium, Squaw Valley, CA, Oct. 5-9, 2003, 543-546. 

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