Porous polymer monolith

Svec, F Frechet, JMJ, Molded Rigid Monolithic Porous Polymers An Inexpensive, Efficient, and Versatile Alternative to Beads for the Design of Materials for Numerous Applications, Industrial and Engineering Chemistry Research 38, 34, 1999. 

Yu, C., Davey, M. H., Svec, F, and Frechet, J. M. (2001). Monolithic porous polymer for on-chip solid-phase extraction and preconcentration prepared by photoinitiated in situ polymerization within a microfluidic device. Anal. Chem. 73, 5088-5096. 

Cooper, A. I. Holmes, A. B. Synthesis of Molded Monolithic Porous Polymers Using Supercritical Carbon Dioxide as the Porogenic Solvent. Adv. Mater. 1999, 11, 1270. 

Microfluidics and miniaturization hold great promise in terms of sample throughput advantages [100]. Miniaturization of analytical processes into microchip platforms designed for micro total analytical systems (/i-TASs) is a new and rapidly developing field. For SPE, Yu et al. [123] developed a microfabricated analytical microchip device that uses a porous monolith sorbent with two different surface chemistries. The monolithic porous polymer was prepared by in situ photoinitiated polymerization within the channels of the microfluidic device and used for on-chip SPE. The sorbent was prepared to have both hydrophobic and ionizable surface chemistries. Use of the device for sorption and desorption of various analytes was demonstrated [123]. 

Fig. 6.20. Schematics for the preparation of monolithic capillary columns. First, the bare capillary is filled with the polymerization mixture (step a) that contains functional monomer, crosslinking monomer, initiator, and porogenic solvent. Polymerization (step b) is then initiated thermally or by UV irradiation to afford a rigid monolithic porous polymer. The resulting monolith within the capillary is washed (step c) with the mobile phase using a pump or electroosmotic flow and used as for the CEC separations.

Svec, F. Frechet, J.M.J. Molded rigid monolithic porous polymers an inexpensive, efficient, and versatile alternative to beads for the design of materials for numerous applications. Ind. Eng. Chem. Res. 1999, 38, 34-48. 

Bakry, R., Bonn, G. K., Mair, D., and Svec, F. 2007. Monolithic porous polymer layer for the separation of peptides and proteins using thin-layer chromatography coupled with MALDI-TOF-MS, Anal. Chem., 79 486 93. 

Yu C et al (2001) Monolithic Porous Polymer for On-Chip Solid-Phase Extraction and Preconcentration Prepared by Photoinitiated in Situ Polymerization within a Microfluidic Device. Anal Chem 73 5088-5096... 

Cooper, A.I. and Holmes, A.B. (1999) Synthesis of molded monolithic porous polymers using supercritical carbon dioxide as the porogenic solvent. Advanced Materials, 11,1270-. 

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