Medaka

Medaka Oryzias iatipes) MBTC 48-h LC50 38 38 Nagase et al. (1991)... 

Medaka (Oryzias latipes) DBTC 28-day NOEC (mortality, growth, and behaviour) 1.8 1.8 Wester Canton (1987)... 

Metcalfe, T.L., Metcalfe, C.D., Kiparissis, Y. et al. (2000). Gonadal development and endocrine responses in Japanese medaka (Oryzias latipes) exposed to o,p -T)DT in water or through maternal transfer. Environmental Toxicology and Chemistry 19, 1893-1900. 

Yokota, H., Seki, M., and Maeda, M. et al. (2001). Life-cycle toxicity of 4-nonylphenol to medaka (Oryzias latipes). Environmental Toxicology and Chemistry 20, 2552-2560. 

Heath, A.G., J.J. Cech, Jr., J.G. Zinkl, and M.D. Steele. 1993. Sublethal effects of three pesticides on Japanese medaka. Arch. Environ. Contam. Toxicol. 25 485-491. 

Medaka, Oryzias latipes 949 vs. 455 White sucker, Catostomus commersoni ... 

Exposed to radiolabeled 2,3,7,8-TCDD for as long as 12 days and then transferred to uncontaminated media for up to 175 days The predicted steady-state BCF for 2,3,7,8-TCDD in medakas is 510,000. But observed whole-body BCF after 12 days was only 24,000 times the water concentration this decreased by 47% after 175 days in uncontaminated media 16... 

Allinson, G., M. Ueoka, and M. Morita. 1994. Effect of dietary 1,3,6,8-tetrachlorodibenzo-p-dioxin on the Japanese freshwater fish Oryzias latipes (medaka) and aquatic snail Indoplanorbis exustus (indohira-makigai). Chemosphere 28 1369-1383. 

Schmeider, P., D. Lothenbach, J. Tietge, R. Erickson, and R. Johnson. 1995. [3H]-2,3,7,8-TCDD uptake and elimination kinetics of medaka (Oryzias latipes). Environ. Toxicol. Chem. 14 1735-1743. 

Shortfin molly, Poecilia mexicana Medaka, Oryzias latipes 12 LC50 (24 h) 5... 

Anderson, R.S. and L.L. Brabacher. 1992. In vitro inhibition of medaka phagocyte chemiluminescence by pentachlorophenol. Fish Shellfish Immunol. 2 299-310. 

MEDAKA, Oryzias latipes Exposed to approximately 5, 40, or 200 pg BaP/L for 6 h, once weekly, for up to 4 weeks 6-10-day-old fish Liver neoplasms at intermediate and high 26 concentration exposures... 

Exposed to approximately 4, 47, or 270 pg BaP/L tor 6 h, once weekly tor 2-4 weeks Hepatic neoplasms at intermediate and high concentration exposures 7,12-dimethylbenz[a]-anthracene was more potent than BaP, and medakas were more sensitive than guppies 26... 

Fabacher, D.L., J.M. Besser, C.J. Schmitt, J.C. Harshbarger, P.H. Peterman, and J.A. Lebo. 1991. Contaminated sediments from tributaries of the Great Lakes chemical characterization and carcinogenic effects in medaka (Oryzias latipes). Arch. Environ. Contam. Toxicol. 20 17-34. 

Hawkins, W.E., W.W. Walker, R.M. Overstreet, J.S. Lytle, and T.F. Lytle. 1990. Carcinogenic effects of some polycyclic aromatic hydrocarbons on the Japanese medaka and guppy in waterborne exposures. Sci. Total Environ. 94 155-167. 

Radiation causes dominant lethal mutations in the medaka (Oryzias latipes) (Shima and Shimada 1991). Mosquitofish (Gambusia spp.) from radionuclide-contaminated ponds in South Carolina differed from conspecifics in reference ponds, as judged by the frequency of DNA markers, and this is consistent with the hypothesis that these DNA markers may originate from genetic elements that provide a selective advantage in contaminated habitats (Theodorakis et al. 1998). Ionizing radiation at low-level chronic exposure reportedly has no deleterious genetic effects on aquatic populations because exposure is compensated by density-dependent responses in fecundity (IAEA 1976). However, this needs verification. 

Medaka, Oryzias latipes adult males receiving single acute exposure of 0.64, 4.75, or 9.5 Gy Dose-dependent increase in total mutations in sperm, spermatids, and spermatogonia 16... 

Shima, A. and A. Shimada. 1991. Development of a possible nonmammalian test system for radiation-induced germ-cell mutagenesis using a fish, the Japanese medaka (Oryzias latipes). Proc. Natl. Acad. Sci. U.S.A. 88 2545-2549. 

Carlson, E.A., Li, Y., and Zelikoff, J.T., Exposure of Japanese medaka (Oryzias latipes) to benzo[a]pyrene suppresses immune function and host resistance against bacterial challenge, Aquat. Toxicol., 56, 289, 2002. 

In a series of studies on 2-amino-A-phenylthiazole (Piscaine), a fish anesthetic, Suzuki and co-workers (24) isolated and identified an N-glucuronide metabolite (2-amino-A-phenylthiazole-2-N-g-mono-D-glucopyranosiduronic acid) from medaka (Oryzias latipes), rainbow trout, and carp (Cyprinus oarpio) (Figure l). 

Suzuki et al. (24) identified a minor biotransformation product of 2-amino- -phenylthiazole in rainbow trout and carp as 2-acetamido-it-(V-hydroxyphenyl )-thiazole (Figure 1). They were unable, however, to demonstrate the presence of this metabolite in the medaka. These authors also suggested that the effectiveness of the 2-amino-A-phenylthiazole as a fish anesthetic is related to the rate at which the drug is activated by biotransformation. 

Rice PJ, Drewes CD, Klubertanz TM, et al. 1997. Acute toxicity and behavioral effects of chlorpyrifos, permethrin, phenol, strychnine, and 2,4-dinitrophenol to 30-day-old Japanese Medaka (Oryzias latipes). Environ Toxicol Chem 16 696-704. 

Phycotoxins accumulate in fish and shellfish because of the natural feeding habits of the respective organisms, rather than because of food handling or processing practices. The toxins causing the diseases discussed in this chapter are heat stable (Australia New Zealand Food Authority, 2001 Committee on Evaluation of the Safety of Fishery Products, 1991). Complete inactivation of saxitoxin (associated with PSP) requires at least ten minutes of exposure to 260°C dry heat. Brevetoxins (associated with NSP) were inactivated (i.e., to levels below the limit of assay detection using Japanese medaka [Oryzias latipes]) by exposure to 500°C heat for 10 to 15 minutes (Poli, 1988). Complete inactivation required 10 minutes exposure to 2760°C dry heat (Wannamacher, 2000). 

LC50 (96-h static bioassay) for rainbow trout 14 mg/L, fathead minnows 12 mg/L, channel catfish 23 mg/L, bluegill sunfish 2 mg/L (quoted, Verschueren, 1983), Japanese medaka Oryzias latipes) 37.7 mg/L (Holcombe et al, 1995). 

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