Major histocompatibility complex expression

Zhu J, Bengtsson BO, Mix E, Thorell LH, Olsson T, Link H (1994) Effect of monoamine reuptake inhibiting antidepressants on major histocompatibility complex expression on macrophages in normal rats and rats with experimental allergic neuritis (EAN). Immuno-pharmacology 27 225-244. 

Hamet, P., Tremblay, J., Malo, D., Kunes, J., Hashimoto, T. (1990b). Genetic hypertension is characterized by the abnormal expression of a gene localized in major histocompatibility complex hsp70. Transplant. Proc. 22,2566-2567. 

Apo E, apolipoprotein E CAD, coronary artery disease FKN, fractalkine MHC, major histocompatibility complex MCP-1, monocyte chemoattractant protein 1 MMPs, matrix metalloproteinases NK, natural killer oxLDL, oxidized LDL RANTES, regulated on activation, normal T cell expressed and secreted VSMCs, vascular smooth muscle cells. 

Vallance, B.A., Galeazzi, F., Collins, S.M. and Snider, D.P. (1999b) CD4 T cells and major histocompatibility complex class II expression influence worm expulsion and increased intestinal muscle contraction during Trichinella spiralis infection. Infection and Immunity 67, 6090-6097. 

Rollins-Smith, L.A., and Blair, R, Expression of class II major histocompatibility complex antigens on adult T cells in Xenopus is metamorphosis-dependent, Dev Immunol., 1, 97, 1990. 

Lymphocytes, the effector cells of the acquired immune system, include morphologically indistinguishable T and B cells, the former divided into CD4+ T helper cells and CD8+ cytotoxic T cells. Since the functions of those cell subsets differ so drastically, it became important to develop tools to distinguish them from each other. Efforts to identify cell subsets according to their expression of different surface antigens have been successful, including various Cluster of Determination (CD) markers (Table 23.1). In addition, cross-reactive monoclonal antibodies, and subsequently developed species-specific polyclonal and monoclonal antibodies towards the major histocompatibility complex (MHC) have been used to label cells in circulation and in tissue sections (Table 23.1). 

Aten, J. et al., (1988) Mercuric chloride-induced autoimmunity in the brown Norway rat. Cellular kinetics and major histocompatibility complex antigen expression. Am. J. Pathol., 133, 127, 1988... 

Suppressor T cells were also shown to express a major histocompatibility complex (MHC) class II marker, I-J. However, because I-J was never cloned and its presence in the MHC never shown formally, there was considerable doubt as to the significance of I-J [reviewed in 3, 4]. 

The coupling of superantigen—major histocompatibility complex class II to T-cell receptor swifdy results in cell-signaling cascades. ° These staphylococcal toxins can increase levels of phosphatidyl inositol from quiescent T cells, such as other mitogens, as well as elicit intracellular Ca movement that activates the protein kinase C (PKC) pathway important for interleukin-2 (IL-2) expression. " IL-2 is intimately linked to T-cell proliferation. In addition to the PKC pathway, the protein tyrosine kinase (PTK) pathway is also activated by superantigens, leading to elevated expression of various proinflammatory cytokines. Staphylococcal superantigens also potently activate transcriptional factors NF-/IB (nuclear factor kappa B) and AP-1 (activator protein-1), which subsequently elicit the synthesis of proinflammatory cytokines. " " ... 

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