Experimental allergic neuritis

P2 protein. PNS myelin contains a positively charged protein different from MBP that is referred to as P2 (Mr — 15,000). It is unrelated in sequence to MBP and is a member of a family of cytoplasmic fatty acid binding proteins (FABP) that are present in a variety of cell types [25]. The amount of P2 protein is variable among species, accounting for about 15% of total protein in bovine PNS myelin, 5% in humans and less than 1% in rodents. P2 protein is generally considered a PNS myelin protein but it is expressed in small amounts in CNS myelin sheaths of some species. P2 is an antigen for experimental allergic neuritis, the PNS counterpart of EAE (see Chs 36 and 38). P2 appears to be present in the major dense line of myelin sheaths, where it may play a structural role similar to MBP... 

Saida, T., Saida, K., Silberberg, D. H. and Brown, M. J. Experimental allergic neuritis induced by galactocerebro-side. Ann. Neurol. 9(Suppl.) 87-101,1981. 

EAN experimental allergic neuritis GnRH gonadotropin-releasing hormone... 

Saida T, Saida K, Dorfman SH (1979b) Experimental allergic neuritis induced by sensitization with galactocerebroside. Science 204 1103-6. 

Zhu J, Mix E, Olsson T, Link H (1994) Cellular messenger-Rna expression of interferon-gamma, 11-4 and transforming growth-factor-beta (Tgf-Beta) by rat mononuclear-cells stimulated with peripheral-nerve myelin antigens in experimental allergic neuritis. Clin Exp Immunol 98 306—312. 

Zhu J, Bai XE, Mix E, Link H (1997) Experimental allergic neuritis Cytolysirr mRNA expression is upregulated in lymph node cells durmg corrvalescerrce. J Neuroimmunol 78 108—116. 

Heininger K, StoU G, Linington C, Toyka KV, Wekerle H (1986) Conduction faUure and nerve conduction slowing in experimental allergic neuritis induced by P2-specific T-ceU hues. Ann Neurol 19 44-49. 

Hahn AF, Feasby TE, Wilkie L, Lovgren D (1993) Antigalactocer-ebroside antibody increases demyefination in adoptive transfer experimental allergic neuritis. Muscle Nerve 16 1174—1180. 

Spies JM, Pollard JD, Bonner JG, Westland KW, McLeod JG (1995a) Synergy between antibody and P2-reactive T cells in experimental allergic neuritis. J Neuroimmunol 57 77-84. 

Zhu J, Bengtsson BO, Mix E, Thorell LH, Olsson T, Link H (1994) Effect of monoamine reuptake inhibiting antidepressants on major histocompatibility complex expression on macrophages in normal rats and rats with experimental allergic neuritis (EAN). Immuno-pharmacology 27 225-244. 

Seeldrayers, P.A., Yasui, D., Weiner, H.L., and Johnson, D., Treatment of experimental allergic neuritis with nedocromil sodium, J. NeuroimmunoL, 25(2-3), 221, 1989. 

In experiments on an animal model of experimental allergic neuritis, a demyelinating disease, treatment with Org 2766 protected the myelinated nerve fibers of the sural nerve from degeneration (Duckers et al., 1994), an action similar to that observed for lesions of the substantia nigra (see Section 6) and for sensory and glial cells in culture (see Section 7). 

Duckers, H.J., Verhaagen J., de Bruijn, E. and Gispen, W.H. (1994). Effective use of a neurotrophic ACTH 4-9 analog in the treatment of a peripheral demyelinating syndrome (experimental allergic neuritis). An intervention study. Brain 117 365-374. 

Nagai, Y., Ikuta, F., and Nagai, Y., 1980a, Neuropathological comparative studies on experimental allergic neuritis (EAN) induced in rabbits by P2 protein-ganglioside complexes, Jpn. J. Exp. Med. 50 453-462. 

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