Macrophage cytokines

Jordana, M., Richards, C., Irving, L.B. and Gauldie, J. (1988). Spontaneous in vitro release of alveolar macrophage cytokines after the intratracheal instillation of bleomycininrats. Am. Rev. Resp. Dis. 137, 1135-1140. 

Bogdan, C., Paik, J., Vodovotz, Y. and Nathan, C. (1992) Contrasting mechanisms for suppression of macrophage cytokine release by transforming growth factor-beta and interleukin-10. Journal of Biological Chemistry 267, 23301-23308. 

Kim, K.H. et al., Acidic polysaccharide from Panax ginseng, ginsan, induces Thl cell and macrophage cytokines and generates LAK cells in synergy with rIL-2, Planta Med, 64, 110, 1998. 

Kitamura M, Suto T, Yokoo T, Shimizu F, Fine LG Transforming growth factor-(Jj is the predominant paracrine inhibitor of macrophage cytokine synthesis produced by glomerular mesangial cells. J Immunol 1996 156 2964-2971. 

Figure 17.33 Killing of myobacteria within a macrophage. Cytokines from ThI cells stimulate fusion of the phagosome, in which myobacteria thrive, with the lysosome, so that the mycobacteria are killed within the phagolysosome by the agents described above.

CN177 Wallace, F. A., E. A. Miles, and P. C. Calder. Activation state alters the effect of dietary fatty acids on pro-inflammatory mediator production by murine macrophages. Cytokine 2000 12(9) 1374-1379. 

TABLE 2.1 Selected Macrophage Cytokine Products and Their Effects... 

Brodbeck WG, Nakayama Y, Matsuda T, Colton E, Ziats NP, Anderson JM. Biomaterial surface chemistry dictates adherent monocyte/macrophage cytokine expression in vitro. Cytokine 2002, 18, 311-319. 

Perkins RC, Scheule RK, Hamilton R, et al. 1993. Human alveolar macrophage cytokine release in response to in vitro and in vivo asbestos exposure. Exp Lung Res 19(l) 55-65. 

Kobzik, L., Huang, S., Paulauskis, J.D. and Godleski, J.J. (1993). Particle opsonization and lung macrophage cytokine response. J. Immunol. 151, 2753-2759. 

Cytokines form a family of proteins including interleukins and lymphokines that are released by cells in the immune system and act as intercellular mediators in immune response. Cytokines are produced by various cell populations, although they are predominantly produced by helper T cells and macrophages. Cytokines that are secreted from lymphocytes are referred to as lymphokines, whereas those secreted by monocytes or macrophages are referred to as monokines. Many lymphokines are also referred to as interleukins (ILs), because they are also capable of affecting leukocyte cellular responses. 

IL-10 endothelial cells, fibroblasts T- and B-lymphocytes, macrophages Cytokine synthesis inhibitory factor, growth of mast cells... 

Goodridge HS, Wilson EH, Harnett W, Campbell CC, Harnett MM, Liew FY (2001) Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonemaviteae. J Immunol 167 940-945 Gounaris K (2002) Nucleotidase cascades are catalyzed by secreted proteins of the parasitic nematode Trichinella spiralis. Infect Immun 70 4917-4924... 

Therapeutic Agents Targeting TNF-oc. The Streptococcus pneumoniae host resistance model is also valuable for evaluating the importance of macrophage cytokines on bacterial host resistance. Human biological therapeutics targeting inhibition of TNF-a have been used to treat inflammatory autoimmune diseases such as rheumatoid arthritis. Decreased TNFa as a result of treatment with monoclonal antibodies (mAb) to TNF-a has an effect on several biomarkers of infection (Takashima et al, 1997 van der Poll et al, 1997 Benton et al., 1998 O Brien et al, 1999). These studies have reported that treatment of mice with a mAb to TNF-a results in altered levels of TNF-a in the lungs... 

Manthey, C.L., and Schuchman, E.H., Acid sphingomyehnase-derived ceramide is not required for inflammatory cytokine signalhng in murine macrophages. Cytokine, 10 (1998) 654-661. 

B cell IgG production, macrophage cytokine production of IL-6 and TNF, and enhancing induction of cytotoxic T cells (Yoshida et al. 1997). 

Wallace, F.A., Miles, E.A., and Calder, P.C. (2000) Activation State Alters the Effect of Dietary Fatty Acids on Pro-Inflammatory Mediator Production by Murine Macrophages, Cytokine 12,1374-1379. 

Goodridge HS, Wilson EH, Harnett W et aL Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthochcilonema viteac. J Immunol 2001 167 940-945. 

Premasekharan, G., Nguyen, K., Contreras, J., Ramon, V., Leppert, V. J., and Forman, H. J. 2011. Iron-mediated lipid peroxidation and hpid raft disruption in low-dose silica-induced macrophage cytokine production. Free adic iQl M 51,1184—1194. 

Turek, J.J., Li, Y., Schoenlein, LA., Allen, K.G.D., and Watkins, B.A. (1998) Modulation of Macrophage Cytokine Production by Conjugated Linoleic Acids Is Influenced by the Dietary n-6 n-3 Fatty Acid Ratio, J. Nutr. Biochem. 9, 258-266. 

H36.12J clonally derived, C57BL/6N-mouse hybrid precursor macrophages were found useful to evaluate the mechanisms by which Be stimulates macrophage cytokine production, and by which T cell derived IFN-y amplifies TNF-a production in granulomatous disease (Sawyer et d. 2000). The response was maximal at 100 jiM BeS04 and did not occur when 12j cells were stimulated with either aluminium sulphate of cobalt sulphate. Beryllium stimulated the production of 725125 pg/ml TNF-a protein by 12j cells as measured by ELISA of culture supernatants after 24 h. As measured by RT-PCR, Be-stimulated 12j cell TNF-a protein production was accompanied by an increased intracellular TNF-a mRNA at 3 and 24 h. The addition of 10 U or 1(X) U of recombinant-Mu-IFN-y to Be-stimulated 12j cells further increased TNF-a production 1.5-4... 

Battiston KG, Ouyang B, Labow RS, Simmons CA, Santerre JP. Monocyte/macrophage cytokine activity regulates vascular smooth muscle cell function within a degradable polyurethane scaffold. Acta Biomater March 2014 10(3) 1146-55. 

Female Fischer 344 rat offspring, 13 weeks old dams bred at 9 weeks Pregnant dams exposed to 0, 100, 250, 500 ppm Pb (acetate) beginning 9 weeks old offspring Pb-exposed only in utero Pb modulated immune, macrophage cytokine and effector functions TNF-o, NO production elevated at 250 ppm decreased DTH reactions in 250 ppm group and IFN in the 500 ppm group Miller et al. (1998)... 

Interieukin-10 is a potent anti-inflammatory cytokine secreted by macrojfiages and T lymphocytes. Its two principal anti-inflammatory functions are the inhibition of macrophage cytokine production and the reduction of T-lymphocyte activation. Itano et al. used an intravenous donor protocol to demonstrate that... 

Kobzik L, Huang S, Paulauskis JD, Godleski JJ. Particle opsonization and lung macrophage cytokine response. In vitro and in vivo analysis. J Immunol 1993 151 2753-2759. 

Driscoll KE, Maurer JK, Higgins J, Poynter J. Alveolar macrophage cytokine and growth factor production in a rat model of crocidolite-induced pulmonary inflammation and fibrosis. J Toxicol Environ Health 1995 46 155-169. 

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