Macrophage, cytokine production

TABLE 2.1 Selected Macrophage Cytokine Products and Their Effects... 

Goodridge HS, Wilson EH, Harnett W, Campbell CC, Harnett MM, Liew FY (2001) Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthocheilonemaviteae. J Immunol 167 940-945 Gounaris K (2002) Nucleotidase cascades are catalyzed by secreted proteins of the parasitic nematode Trichinella spiralis. Infect Immun 70 4917-4924... 

B cell IgG production, macrophage cytokine production of IL-6 and TNF, and enhancing induction of cytotoxic T cells (Yoshida et al. 1997). 

Goodridge HS, Wilson EH, Harnett W et aL Modulation of macrophage cytokine production by ES-62, a secreted product of the filarial nematode Acanthochcilonema viteac. J Immunol 2001 167 940-945. 

Premasekharan, G., Nguyen, K., Contreras, J., Ramon, V., Leppert, V. J., and Forman, H. J. 2011. Iron-mediated lipid peroxidation and hpid raft disruption in low-dose silica-induced macrophage cytokine production. Free adic iQl M 51,1184—1194. 

Turek, J.J., Li, Y., Schoenlein, LA., Allen, K.G.D., and Watkins, B.A. (1998) Modulation of Macrophage Cytokine Production by Conjugated Linoleic Acids Is Influenced by the Dietary n-6 n-3 Fatty Acid Ratio, J. Nutr. Biochem. 9, 258-266. 

H36.12J clonally derived, C57BL/6N-mouse hybrid precursor macrophages were found useful to evaluate the mechanisms by which Be stimulates macrophage cytokine production, and by which T cell derived IFN-y amplifies TNF-a production in granulomatous disease (Sawyer et d. 2000). The response was maximal at 100 jiM BeS04 and did not occur when 12j cells were stimulated with either aluminium sulphate of cobalt sulphate. Beryllium stimulated the production of 725125 pg/ml TNF-a protein by 12j cells as measured by ELISA of culture supernatants after 24 h. As measured by RT-PCR, Be-stimulated 12j cell TNF-a protein production was accompanied by an increased intracellular TNF-a mRNA at 3 and 24 h. The addition of 10 U or 1(X) U of recombinant-Mu-IFN-y to Be-stimulated 12j cells further increased TNF-a production 1.5-4... 

Interieukin-10 is a potent anti-inflammatory cytokine secreted by macrojfiages and T lymphocytes. Its two principal anti-inflammatory functions are the inhibition of macrophage cytokine production and the reduction of T-lymphocyte activation. Itano et al. used an intravenous donor protocol to demonstrate that... 

Interleukin-10 (IL-10) affects antigen presentation capacity but also interferes with many other functions of monocytes and macrophages (Table 2) (F8). In vitro, IL-10 is a potent inhibitor of cytokine production, including production of TNF, IL-1, IL-6, and IL-8 by LPS-activated monocytes/macrophages (F8). It also inhibits tissue factor-dependent procoagulant activity induced by LPS in human... 

Intratracheal instillation 14d Alveolar macrophages activation production pro-inflammatory cytokines Blood high-levels pro-inflammatory cytokines differentiation of CD4+ T cell to Thl and Th2 cells [108]... 

Cho SY, Park SJ, Kwon MJ, Jeong TS, Bok SH, Choi WY, Jeong WI, Ryu SY, Do SH, Lee CS, Song JC and Jeong KS. 2003. Quercetin suppresses proinflammatory cytokines production through MAP kinases andNF-kappaB pathway in lipopolysaccharide-stimulated macrophage. Mol Cell Biochem 243(1-2) 153-160. 

Burger, R.A. et al., Echinacea-induced cytokine production by human macrophages, Int J Immunopharmacol, 19, 371, 1997. 

Early research showed that Pb exposure could increase sensitivity to bacterially-derived endotoxins [63] as well as increase production of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-a) by macrophages [64-67], Studies in several species indicate that Pb boosts production of TNF-a both immediately following adult exposure and in later life following gestational exposure. Flohe and coworkers [67] reported that Pb-induced elevation in TNF-a production is sensitive to both protein kinase C signaling as well as protein production. Not only can the production of TNF-a be elevated following exposure to Pb, but also the expression of the receptor for TNF-a (TNF-R) is elevated [68], Therefore, the combined effect of elevated cytokine production by macrophages as well as increased receptor expression would be expected to contribute to problematic inflammatory responses. 

CN177 Wallace, F. A., E. A. Miles, and P. C. Calder. Activation state alters the effect of dietary fatty acids on pro-inflammatory mediator production by murine macrophages. Cytokine 2000 12(9) 1374-1379. 

The receptor for l,25(OH)2D exists in a wide variety of tissues—not just bone, gut, and kidney. In these "nonclassic" tissues, l,25(OH)2D exerts a number of actions including regulation of parathyroid hormone secretion from the parathyroid gland, insulin secretion from the pancreas, cytokine production by macrophages and T cells, and proliferation and differentiation of a large number of cells, including cancer cells. Thus, the clinical utility of l,25(OH)2D and its... 

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