Non-Hodgkin lymphoma

Methotrexate Inhibits DHFR inhibits TS inhibits de novo purine nucleotide synthesis Breast cancer, head and neck cancer, osteogenic sarcoma, primary central nervous system lymphoma, non-Hodgkin s lymphoma, bladder cancer, chorioca rcinoma Mucositis, diarrhea, myelosuppression with neutropenia and thrombocytopenia... [Pg.1170]

Melanoma of the skin Non-Hodgkin s lymphoma Non-Hodgkin s lymphoma Ovary... [Pg.229]

Non-Hodgkin lymphoma Non-Hodgkin lymphoma Leukemia Ovary... [Pg.544]

Interferon alfa-2b Intron A (Schering-Plough) Hairy cell leukemia AIDS-related Kaposi s sarcoma chronic hepatitis, types B and C condylomata acuminata malignant melanoma follicular lymphoma non-Hodgkins lymphoma... [Pg.271]

Pentostatin is extremely effective in prodncing complete remissions in the hairy cell. Complete responses of 58% and partial responses of 28% have been reported, even in patients who were refractory to interferon-alfa. Activity also is seen against chronic lymphocytic leukemia (CLL), chronic myeiogenous leukemia (CML), promyelocytic leukemia, cutaneous T-cell lymphoma, non-Hodgkin s lymphoma, and Langerhans cell histiocytosis. Pentostatin has no signihcant activity against solid tnmors or mnltiple myeloma. [Pg.560]

Pediatric acute lymphocytic leukemia, osteogenic sarcoma, Burkitts lymphoma, non-Hodgkin s lymphoma, breast, head, neck, small cell lung, choriocarcinoma, psoriasis, rheumatoid arthritis. [Pg.127]

Epstein-Barr virus Infectious mononucleosis Burkitfs lymphoma Non-Hodgkin s lymphoma Hodgkin s disease Nasopharyngeal carcinoma... [Pg.10]

Vascular tmnors Angiosarcoma Hemangiosarcoma Epithelioid hemangioendothelioma Leiomyosarcoma Fibrosarcoma Embryonal sarcoma Fibrous histiocytoma Lymphoma (Hodgkin s disease) Lymphoma (non-Hodgkin s disease)... [Pg.239]

Poly(ethylene glycol) (PEG) molecules attached to adenosine deaminase (ADA) have been used in patients exhibiting symptoms of the severe combined immunodeficiency syndrome (SCID) caused by ADA deficiency. The modified enzyme has a plasma half-life of weeks as compared to the unmodified enzyme (minutes) (248). PEG-L-asparaginase has induced remissions in patients with non-Hodgkin s lymphoma (248). However, one disadvantage of PEG-enzyme treatment is its expense, ie, a year s treatment costs about 60,000 (248). [Pg.312]

Bendamustine is a useful antineoplastic drug for the treatment of non-Hodgkin s lymphomas, multiple myeloma and as a partner drug in the combination therapy of some solid tumors. The cross-resistance with other alkylating drugs is not complete. Myelosuppression and lymphocytopenia is its main dose-limiting toxicity. [Pg.57]

Liposomal encapsulation of DOX or DNR Preferred anthracycline delivery to the tumor Breast cancer, ovarian cancer, AIDS-related Kaposi s sarcoma, multiple myeloma (pegylated liposomal DOX). Breast cancer (uncoated liposomal DOX). AIDS-related Kaposi s sarcoma, acute mye-loblastic leukemia, multiple myeloma, non-Hodgkin s lymphomas (uncoated liposomal DNR)... [Pg.95]

An update of a previous study (Axelson et al. 1978), Axelson (1986) evaluated an expanded cohort of 1,424 men (levels of trichloroethylene exposure inferred from measured urinary metabolite concentrations) and found a significant increase in incidences of bladder cancer and lymphomas, and a lower than expected incidence of total cancer mortality. A further update of this work (Axelson et al. 1994) expanded the cohort to include 249 women, tracking cancer morbidity over 30 years, and found no correlation between exposure concentration or exposure time and cancer incidence at any site. The highest standardized incidence ratio noted in this study was 1.56 (95% Cl of 0.51-3.64) for 5 cases of non-Hodgkin s lymphoma observed in men. Although four of these cases occurred in persons exposed for at least 2 years, and 3 cases had a latency of 10 years or more, urinary levels of TCA showed that 4 of the 5 cases were exposed to the lowest levels of trichloroethylene (urinary levels of TCA 0-49 mg/L). The study authors mentioned that a urinary TCA level below 50 mg/L corresponds to a trichloroethylene exposure concentration of about 20 ppm. The study authors concluded that "this study provides no evidence that trichloroethylene is a human carcinogen, i.e., when the exposure is as low as for this study population."... [Pg.59]

Cohn P, Klotz J, Bove F, et al. 1994. Drinking water contamination and the incidence of leukemia and non-Hodgkin s lymphoma. Environ Health Perspect 102 556-561. [Pg.258]

Hardell L, Eriksson M, Degerman A. 1994. Exposure to phenoyacetic Acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin s lymphoma. [Pg.269]

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