Non-Hodgkin’s lymphoma classification

Al. A clinical evaluation of the International Lymphoma Study Group classification of non-Hodgkin s lymphoma. The Non-Hodgkin s Lymphoma Classification Project. Blood 89, 3909-3918 (1997). 

Mantle cell lymphoma (MCL) is one of the new disease entities previously unrecognized by other classification systems. This histologic type was found in 6% of cases in the International Non-Hodgkin s Lymphoma Classification Project. The chromosomal translocation t(l 1 14) occurs in most cases of MCL. MCL usually occurs in older adults, particularly in men, and most patients have advanced disease at the time of diagnosis (see Table 129-8). Extranodal involvement is found in about 90% of cases. The course of the disease is moderately aggressive the median overall survival is about 3 years, with no evidence of a survival plateau. 

The Non-Hodgkin s Lymphoma Classification Project National Cancer Institute sponsored study of classifications of non-Hodgkin s lymphomas. Summary and description of a working formulation for clinical usage. Cancer 1982 49 2112-2135. 

Anderson JR, Armitage JO, Weisenburger DD. Epidemiology of the non-Hodgkin s lymphomas distributions of the major subtypes differ by geographic locations. Non-Hodgkin s Lymphoma Classification Project. Ann Oncol. 1998 9(7) 717-720. 

Delineate the clinical course of follicular indolent and diffuse aggressive non-Hodgkin s lymphoma and the implications for disease classification schemes and treatment goals. 

Lymphomas are a heterogenous group of malignancies that arise from immune cells residing predominantly in lymphoid tissues. Differences in histology have led to classification as Hodgkin s and non-Hodgkin s lymphoma (HL and NHL, respectively), which are addressed separately in this chapter. 

The current classification system for non-Hodgkin s lymphoma is the Revised European-American Classification of Lymphoid Neoplasms and World Health Organization (REAL-WHO) classification system, which is based on the principle that a classification is a list of specific disease entities defined by a combination of morphology, immunophe-notype, genetic features, and clinical features. 

Trumper LH, Brittinger G, Diehl V, Harris NL. Non-Hodgkin s lymphoma a history of classification and clinical observations. In Mauch PM, Armitage JO, Coiffier B, et al, eds. Non-Hodgkin s Lymphomas. Philadelphia, Lippincott Williams Wilkins, 2004 3-19. 

Meijet CJ, van det Valk P, de Bruin PC, et al. The tevised Eutopean-American lymphoma (REAL) classification of non-Hodgkin s lymphoma a missed opportunity Blood. 1995 85(7) 1971-1972. 

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