Lung cancer transplant

Gasa, S., and Makita, A. Phosphorylation on protein and carbohydrate moieties of a lysosomal arylsulfatase B variant in human lung cancer transplanted into athymic mice. J. Biol. Chem. 258, 5034-5039 (1983). 

Cyclophosphamide is a component of CMF (cyclophosphamide, methotrexate, 5-fluorouracil) and other drug combinations used in the treatment of breast cancer. Cyclophosphamide in combination may produce complete remissions in some patients with ovarian cancer and oat cell (small cell) lung cancer. Other tumors in which benehcial results have been reported include non-oat cell lung cancers, various sarcomas, neuroblastoma, and carcinomas of the testes, cervix, and bladder. Cyclophosphamide also can be employed as an alternative to azathioprine in suppressing immunological rejection of transplant organs. 

Unlabeled Uses Adrenocortical, bladder, cervical, endometrial, prostatic, testicular carcinomas Ewing s sarcoma multiple sclerosis non-small cell, small cell lung cancer organ transplant rejection osteosarcoma ovarian germ cell, primary brain, trophoblastic tumors rheumatoid arthritis soft tissue sarcomas systemic dermato-myositis systemic lupus erythematosus Wilms tumor... 

Pham SM, Kormos RL, Landreneau RJ, Kawai A, Gonzalez-Cancel I, Hardesty RL, Hattler BG, Griffith BP. Sohd tumors after heart transplantation lethahty of lung cancer. Ann Thoracic Surg 1995 60 1623-6. 

ALL, acute lymphocytic leukemia ANLL, acute non lymphocytic leukemia BMT, bone marrow transplantation BP, blood pressure CIcr, creatinine clearance HD, Hodgkin s disease KS, Kaposi s sarcoma LVEF, left ventricular ejection fraction MDS, myelodysplastic syndrome NHL, non-Hodgkin s lymphoma NSCLC, non-small-cell lung cancer SCLC small cell lung cancer. 

Gasa, S., Makita, A., Kameya, T., Kodama, T., Koide, T., Tsumuraya, M., and Komai, T., Arylsul tases of human-lung tumors transplanted into alythmic mice—Cancer assoeiated modification of arylsulfatase B variant. Eur. J. Biochem. 116, 497-503 (1981). 

Johnson WM, Baldursson O, Gross TJ (1998) Double jeopardy lung cancer after transplantation. Chest 113 1720-1723... 

Potaris K, Radovancevic B, Thomas CD, Gregoric I, Vapor-ciyan AA, Riggs SA, Radovancevic R, Vaugh WK, Frazier OH (2005) Lung cancer after heart transplantation 17-year experience. Ann Thoracic Surg 79 980-983... 

The first human lung transplantation (LuTX) was performed hy Dr James Hardy (Hardy et al. 1963) in June 1960 at the University of Mississippi in a patient with unresectahle lung cancer and obstructive pneumonitis. The patient received immunosuppression with azathioprine (Aza) and irradiation, hut he died due to renal failure after 17 days. 

Bronchogenic carcinoma develops in the native lung of transplant recipients with emphysema and pulmonary fibrosis at frequencies of 2% and 4%, respectively. The carcinomas most commonly manifest as a pulmonary nodule or mass on chest radiographs, with more nodules seen on CT scans (Collins et al. 2002). This rate is similar to that in other high-risk populations (e.g. elderly smokers with emphysema or other chronic lung disease). The majority of cancers are associated with a poor prognosis. The most common imaging manifestations are a solitary pulmonary nodule or mass. 

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