Athymic mice

YCUNG H J, DCERGE D R, KIMBERLY F A, ALLRED C D and HELFERICH W G (2002) Dietary genistein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 62,2474-77. 

Figure 2. Effects of MVE-hy-MTX, MTX-hy and MVE on human leukemia HL60 in athymic mice.

Araki E, Ishikawa M, Iigo M et al. Relationship between development of diarrhea and the concentration of SN-38, an active metabolite of CPT-11, in the intestine and the blood plasma of athymic mice following intraperitoneal administration of CPT-11. Jpn J Cancer Res 1993 84 697-702. 

Block of endometrial tumor progression Athymic mice ICI 164384 (Gottardis et al. 1990)... 

When studied in a model of human endometrial carcinoma, such as EnCa 101 tumors in athymic mice, ICI 164384 not only showed no stimulatory activity on tumor progression but also blocked the tamoxifen-stimulated growth of the tumor (Gottardis et al. 1990). 

Gottardis MM, Ricchio ME, Satyaswaroop PG, Jordan VC (1990) Effect of steroidal and nonsteroidal antiestrogens on the growth of a tamoxifen-stimulated human endometrial carcinoma (EnCalOl) in athymic mice. Cancer Res 50 3189-3192... 

Interestingly, after intravenous administration of a radiolabelled folate conjugate ( -In-dium-diethylenetriaminepenta acid (DTPA)-folate) in the rat, the conjugate was rapidly excreted in the urine. Moreover, after intravenous administration to athymic mice with a human tumour cell implant, the radiotracer was not only taken up by the subcutaneous tumour but was also taken up by the kidneys in significant quantities [63], indicating substantial renal selectivity of the folate conjugate. In addition to the kidney, the liver also has a high concentration of the folate-receptor [64]. 

Masui H, Kawamoto T, Sato JD, et al. Growth inhibition of human tumor cells in athymic mice by anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 1984 44 1002-1007. 

Fig. 2. Matrigel plug assay results. Matrigel was implanted subcutaneously into athymic mice on d 0 (8-10 mice per group). Daily BMS-275291 oral treatments began on d 0 and continued to d 6. Matrigel plugs were harvested on d 7 and processed for histochemical analyses. Results are expressed as % Inhibition SE (% Relative to Untreated Control).

Piccoli R, Olson KA, Vahee BL, Fett JW. 1998. Chimeric anri-angiogenin antibody cAb 26-2F inhibits the formation of human breast cancer xenograft in athymic mice. PNAS USA. 95 4579-4583. 

Wei, M.X., Tamiya, T., Hurford, Jr., R.K., Boviatsis, E.J., Tepper, R.I. and Chiocca, E.A. (1995) Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retro viral gene transfer. Gene Ther., 6, 437-443. 

The in vivo antitumor activity of 78 was evaluated against A151 human ovarian carcinoma xenograft in nude athymic mice, and was found to be equivalent or slightly better than that of paclitaxel, causing total regression of the tumor.94... 

Establishing Orthotopic HT-29LP Tumors in Nu/Nu Athymic Mice... 

Zhang, L., Lau, Y.-K., Xia, W., Hortobagyi, G. N., and Hung, M.-C., 1999. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clin. Cancer Res. 5, 343-353. 

We and others have demonstrated that Raf-1 protein serine/threonine kinase is a druggable signaling molecule in cancer therapy (1,13,17,21-25). Our laboratory has developed a novel cationic liposomal formulation for systemic delivery of intact raf ASO (LErafAON) to normal and tumor tissues in mice (13,17). The liposome-entrapped raf antisense oligonucleotide (LErafAON) is also the first liposomal ASO drug tested in humans (26,27). Systemically delivered cationic liposomal nanoparticles containing rafsiRNA (LErafsiRNA) also inhibit Raf-1 protein expression in tumor and most normal tissues in human prostate tumor (PC-3)-bearing athymic mice (Fig. 1 and Color Plate 1, see Color Plate Section). 

Examples of the effects of systemically delivered md-LErafAON on Raf-1 expression in normal and tumor tissues and on prostate tumor growth in athymic mice are shown in Fig. 6. 

Hurwitz E, Adler R, Shouval D, Takahashi H, Wands JR, Sela M. Immunotargeting of daunomycin to localized and metastatic human colon adenocarcinoma in athymic mice. Cancer Immunol Immunother 1992 35 186-92. 

The effect of rHuKGF on the proliferation rate of 41 tumor lines was assessed as well as the effect on the growth of subcutaneous receptor positive human tumor xenografts in athymic mice. One tumor showed a statistically significant positive. The overall data to predict potential for tumor promotion in humans were deemed questionable. 

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