AIF-Mediated Cell Death

AIF may contribute to acute neuronal injury induced by trauma, hypoglycemia or transient ischemia as well as in chronic neurodegeneradve diseases (Table 3). The translocadon of AIF has been observed in different experimental models of neurotoxicity including death of photoreceptors induced by rednal detachment, neuronal cell death induct in vivo by brain trauma and cerebral ischemia and death of cortical neurons induced in vitro by exposure to 

Common Features PARP-1/AIF-Mediated Cell Death Caspase-Mediated Cell Death 

not determined no activity +, weak activity ++, strong activity 

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Kolthur-Seetharam U, Dantzer F, McBurney MW, de Murcia G, Sassone-Corsi P (2006) Control of AIF-mediated Cell Death by the Functional Interplay of SIRTl and PARP-1 in Response to DNA Damage. Cell Cycle 5... 

TMe 3. FARP-mediated and AIF-mediated cell death pmgrams in different injury models... 

Table 2. Molecular and morphological features in PARP-1/AIF- and caspase-mediated cell death...

While the role of the over activation of PARP-1 in DNA damage-induced necrotic cell death is now widely accepted, its role in apoptosis appears to hugely depend on the experimental conditions such as the cell type and nature of the stimulus. Nonetheless, Valina Dawson s group has shown that PARP activation is required for activation of the mitochondrial route of apoptosis, charaaerized by mitochondrial depolarization, release of AIF ftx>m the mitochondria to the cytosol and caspase-independent, AIF-mediated apoptosis. Notably, these findings are in line with our previous observation that PARP activation mediates mitochondrial alterations during peroxynitrite or hydrogen peroxide-induced necrotic thymocyte death. At the... 

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