Naphthalene carboxylic acid

These arotinoids, which were first introduced for the treatment of skin diseases, may also have potential as anticancer diugs. For example, the synthetic retinoid 6-[3-(l-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) has been shown to induce apoptosis in a variety of cancer cells including lung cancer cells in vitro, and studies concerning the use of this agent in vivo would be desirable. 

Recently, a large anionic pigment has been intercalated into an LDH host by ion-exchange of an Mg/Al LDH nitrate precursor with a solution of C.I. Pigment Red 48 2 (the calcium salt of 4-((5-chloro-4-methyl-2-sulfophenyl)azo)-3-hydroxy-2-naphthalene-carboxylic acid), in ethane-1,2-diol [215]. The UV-visible diffuse reflectance spectra of C.I. Pigment Red... 

Methoxy-7-methoxycarbonyl-1,2,3,4-tetrahydronaphthalene 2-Naphthalene-carboxylic acid, 5,6,7,8-tetrahydro-3-methoxy-, methyl ester (78112-34-2), 65, 98 Methyl acrylate (96-33-3), 66, 54, 59 dimerization by Pd(II), 66, 52 Methylamine, N-benzylidene-, 65, 140 METHYL 4-0-BENZOYL-6-BROMO-6-DEOXY-a-0-GLUCOPYRANOSIDE ... 

Hydroxyzine pamoate is designated chemically as l-(p-chlorobenzhydryl)4-[2-(2-hydroxyethoxy) ethyl] diethyl-enediamine salt of l.l -methylene bis (2 hydroxyl-naphthalene carboxylic acid). Hydroxyzine pamoate 25 mg/5... 

Walther et al. improved the Na0Ph/C02 system by tuning the role of the solvent, such that the carboxylation of acetone was carried out selectively by sodium phenoxide with N-methyl-caprolactam under 0.1 MPa C02 to afford 3-ketoglutaric acid in 65% yield [34]. The same authors reported the conversion of acetyl-naphthalene (acetonaphthone) to acetyl-naphthalene carboxylic acid with 84% yield, and of cyclohexanone to cyclohexane-2,6-dicarboxylic acid in 56% yield. 

Methoxy-7-methoxycarbony1-1,2, 3,4-tet rahydronaphthalene 2-Naphthalene-carboxylic acid, 5,6,7,8-tetrahydro-3-methoxy-, methyl ester (10) ... 

In a stndy of retention of aromatic carboxylic acids under IPC conditions, linear free energy relationships were observed between the capacity factors and the extraction eqnilibrinm constants of benzoic acid and naphthalene carboxylic acid. The capacity factor of benzene polycarboxylic acids was directly related to then-association constants and qnatemary ammonium ions calculated on the basis of an electrostatic interaction model [27,28],... 

In the naphthalene carboxylic acid series [structure type II, aromatic B, D, and E rings, no C ring], incorporation of a methyl group para to C-6 or at C-19 does not result in a significant loss of activity. However, incorporation of a methyl group at C-10 results in loss of activity. 

Reaction between full (2,3-2-0-acetyl-6-deoxy-6-iodine)-/3-CD and 6-hydroxy-2-naphthalene carboxylic acid methyl ester could generate the whole (2,3-di-0-acetyl-6-0-2-naphthyl methyl)-/S-CD in the NaH/DMF solution [10]. 

Amino-2-naphthalene-carboxylic acid 3-Amino-2-naphthoic acid C HgNOj 5959-52-4 187.195 ye If (dil al) 216.5 s EtOH, eth... 

A final synthetic effort in the yohimbine alkaloid area concerns the studies reported by Loewenthal and his coworkers (Scheme 3.92) (143). The aim was to develop an efficient method to prepare the bicyclic enone 21, which serves as a key intermediate in the Woodward reserpine synthesis strategy (19). The route for preparation of 21 began with Friedel Crafts reaction of 2-methoxynaphthalene (523) with the oxalyl chloride equivalent 524, a process which afforded the acenaphthenoquinone 525. Oxidative-decarboxylation of 525 yielded the naphthalene-carboxylic acid 526 which was transformed by Birch reduction and esterification to the dihydro-derivative 527. Carboxyla-tion then provided geminal diester 528 which was epoxidized. Sequential lactonization and methylation afforded tricyclic lactone 529. Ester cleavage with subsequent decarboxylation gave lactone 530 which was demethylated to provide 531. While no further effort was given to the development of this... 

Similar decomposition mechanisms have been found with other Pseudomonas strains (including P. multivorans) and with monomethyl and dimethyl naphthalenes, for example to methyl salicylic acids and to dimethyl salicylic acids (if both methyl groups were present in the same nucleus of the naphthalene), or to methyl naphthalene carboxylic acids [51]. On the other hand, Cunninghamella el-egans metabolizes naphthalene to trans-l,2-dihydrodiol, from which 1-naphthol, 1,4-naphthoquinone and 4-hydroxy-1-tetralone are formed as intermediates for further decomposition [126, 127]. 

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