Liquid chromatography-nuclear analysis

Pullen, F. S., Swanson, A. G., Newman, M. J. and Richards, D. S., On-line liquid chromatography/nuclear magnetic resonance spectrometry — a powerful spectroscopic tool for the analysis of mixtures of pharmaceutical interest, Rapid Comm. Mass. Spectr., 9, 1003, 1995. [Pg.96]

Pullen, F.S. Swanson, A.G. Newman, M.J. Richards, D.S. Qn-line Liquid Chromatography/Nuclear Magnetic Resonance Mass Spectrometry—A Powerful Spectroscopic Tool for the Analysis of Mixtures of Pharmaceutical Interest, Rapid Comm. Mass Spectrom. 9(11), 1003-1006 (1995). [Pg.429]

Attempts to optimize the yield were unsuccessful. The main parameters affecting the yield of the Fischer indole reaction are the added acid (AcOH > TFA > HCl > H2SO4) as well as the solvent composition, hi pure water, no reaction was observed, whereas in pure acetic acid, we mainly observed the degradation of the 4-methylhydrazine as evidenced by hydrogen nuclear magnetic resonance ( H NMR) and high-performance liquid chromatography (HPLC) analysis. The best compromise was to perform the Fischer indole reaction in a 75/25 ACOH/H2O mixture at 80°C (Table 6.1). [Pg.93]

Yang Z. Online hyphenated liquid chromatography-nuclear magnetic resonance spectroscopy-mass spectrometry for drug metabolite and nature product analysis. J Pharm Biomed Anal 2006 40 516-527. [Pg.367]

See also Extraction Solid-Phase Extraction. Food and Nutritional Analysis Oils and Fats Fruits and Fruit Products. Lab-on-a-Chip Technologies. Liquid Chromatography Liquid Chromatography-Nuclear Magnetic Resonance Spectrometry. Nuclear Magnetic Resonance Spectroscopy Oven/iew Principles Instrumentation. Nuclear Magnetic Resonance Spectroscopy Applications Food. Nuclear Magnetic Resonance Spectroscopy Techniques Solid-State. Peptides. Radiochemical Methods Radiotracers Pharmaceutical Applications. [Pg.3287]

See also-. Bioassays Overview. Chemometrics and Statistics Multivariate Calibration Techniques. Infrared Spectroscopy Near-Infrared. Liquid Chromatography Size-Exclusion Liquid Chromatography-Mass Spectrometry Liquid Chromatography-Nuclear Magnetic Resonance Spectrometry. Pharmaceutical Analysis Drug... [Pg.3622]

Albert, K. Schlotterbeck, G. Tseng, L.-H. Braumann, U. Application of on-line capillary high-performance liquid chromatography-nuclear magnetic resonance spectrometry coupling for the analysis of vitamin A derivatives. [Pg.1350]

Main Applications of Liquid Chromatography-Nuclear Magnetic Resonance (LC-NMR) in the Analysis of Food Flavonoids... [Pg.192]

The development of hyphenated techniques for rapid separation of mixtures and spectroscopic analysis of its components is a topic of great interest, particularly when the amount of sample is limited and the need for automatization is high. This is the case for high-pressure liquid chromatography nuclear magnetic resonance-mass spectroscopy (HPLC NMR-MS), which has been shown to be extremely useful in certain pharmaceutical and medical applications. [Pg.93]

Very little in the way of advances has occurred since 1971 in the applications of ultraviolet or infrared spectroscopy to the analysis of fluonnated organic compounds Therefore, only gas-liquid chromatography, liquid chromatography, mass spectrometry, and electron scattering for chemical analysis (ESCA) are discussed The application of nuclear magnetic resonance (NMR) spectroscopy to the analysis of fluonnated organic compounds is the subject of another section of this chapter... [Pg.1029]

Hyphenated analytical techniques such as LC-MS, which combines liquid chromatography and mass spectrometry, are well-developed laboratory tools that are widely used in the pharmaceutical industry. Eor some compounds, mass spectrometry alone is insufficient for complete structural elucidation of unknown compounds nuclear magnetic resonance spectroscopy (NMR) can help elucidate the structure of these compounds (see Chapter 20). Traditionally, NMR experiments are performed on more or less pure samples, in which the signals of a single component dominate. Therefore, the structural analysis of individual components of complex mixtures is normally time-consuming and less cost-effective. The... [Pg.14]