Mass spectrometry process

T.E. Kaltenbach, T.B. Colin and N. Redden, Chemometric modeling for process mass spectrometry applications, AT-PROCESS, 3, 43-52 (1997). 

Kaltenbach, T.F., Colin, T.B. and Redden, N., Chemometric Modeling for Process Mass Spectrometry Applications AT-Process 1997, 3, 43-52. 

The atomic/molecular weights of atoms or molecules in a mixture are determined with a mass spectrometer. The sample is vaporized, this gas is ionized, and these ions are deflected towards a magnet that separates them according to their mass. There are many specialized applications of mass spectrometry so there are dozens of variations to the process. Mass spectrometry is used to determine the ratio of 2H/1H in water, for 14C dating, and to characterize polymers and biological molecules with molecular weights of over a million. 

How mass spectra are produced largely determines the kind of information in the spectra (1, 2). Mass spectrometry differs from absorbance or emission spectroscopy in that it is a destructive technique, consuming sample used during the measurement process. Mass spectrometry is also a very sensitive technique, consuming as little as a few attomoles (10 moles, or 10 molecules) in the best cases, more typically requiring form 1 to 10 femtomoles (10 moles) for the routine quantitative analyses common in the pharmaceutical industry. 

Pu JRR-3 spent fuel Purex process Mass spectrometry 1968 6... 

Smith, C.A. et al., XCMS Processing mass spectrometry data for metabolite profiling using nonlinear peak alignment, matching, and identification, Anal. Chem., 78(3), 779, 2006. 

Smith, C. A., Want, E. J., Tong, G. C., Abagyan, R. Siuzdak, G. (2006). XCMS Processing Mass Spectrometry Data for Metabolite Profiling Using Nonlinear Peak Alignment, Matching, and Identification, Anal. Chem. 78 779-787. 

Process mass spectrometry (MS) is a very powerful technique for process monitoring and control, providing a unique combination of speed, selectivity, dynamic range, accuracy, precision and flexibility. The technique has become a standard for gas-phase analysis in several industrial applications, including steel manufacturing, fermentation off-gas analysis, and the production of ethylene oxide and ammonia. Among its attributes ... 

Table 19.4 summarises the main relevant characteristics of process mass spectrometry. 

Process MS is a reliable technique that can provide rapid and precise multicomponent analysis on process streams. The ability to monitor multiple sample points with a single analyzer makes MS very economical for many applications, even with the high cost of the analyzer itself Maintenance requirements on modern MS analyzers are on a par with or lower than most other analyzer technologies. In addition to permanent installations for routine process control, these attributes also make process mass spectrometry extremely useful for process development and troubleshooting. 

Colin T (1997) Process mass spectrometry as a tool for process understanding. Journal of Process Analytical Chemistry II 410-415. 

Traynor P (1998) Developments in process mass spectrometry. Journal of Process Analytical Chemistry IV 33-38. 

In order to control the chemical composition and microstructure of the final ceramic produce, it is of great value to understand the nature, rates, and mechanisms of the gaseous product evolution at various stages of the thermal conversion process. Mass spectrometry (MS) in conjunction with TGA provides useful suggestions about the reaction mechanisms responsible for the mass loss. XRD and solid state NMR ( B, N, and Si) becomes a powerful tool to... 

Owen, A.W., Nordon, A., Littlejohn, D., Lynch, T.P., Lancaster, J.S., Wright, R.G. (2014) Qn-line Detection and Quantification of Trace Impurities in Vaporisable Samples by Direct Liquid Introduction Process Mass Spectrometry. Anal. Meth. 6 8148-8153. 

Demirev P (1995) Particle-induced desorption in mass spectrometry. Part I Mechanism and processes. Mass Spectrometry Reviews 14 279-308. 

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