Lipid peroxidation curcumin

It has been known since the early 1950s that turmeric had strong antioxidant effects with curcumin being the major compound responsible followed by demethoxycurcumin and bisdemethoxycurcumin. All three inhibit lipid peroxidation and have a positive anti-oxidant effect for hemolysis and lipid peroxidation in mouse erythrocytes.11 Curry pills containing turmeric are being marketed as a prevention for colon cancer.29... 

The antioxidant activity of curcumin has been investigated for over 30 years [Sharma, 1976], Curcumin has been shown to inhibit lipid peroxidation,... 

Moreover, under certain conditions these phenolic compounds could also act as pro-oxidants. In the presence of redox-active metal ions such as Cu or Fe, phenolic compounds react with O2 to generate phenoxyl radicals. Under normal growth conditions phenoxyl radicals can be rapidly deactivated by polymerization or enzymatic reduction. However, if the phenoxyl radical concentrations are too high and/or the lifetime is increased, they could initiate DNA damage or lipid peroxidation and exhibit cytotoxicities. Curcumin, demethoxycurcumin, and bisdemethoxycurcumin have been reported to induce... 

Daniel S, Limson JL, Dairam A, Watkins GM, Daya S. 2004. Through metal binding, curcumin protects against lead- and cadmium-induced lipid peroxidation in rat brain homogenates and against lead-induced tissue damage in rat brain. J Inorg Biochem 98 266-275. 

Curcumin also has the potential to prevent oxidative damage to the arterial wall. Thus, administration of 500mg of curcuminoids daily to healthy humans for 7 days reduced lipid peroxides by 33% and blood... 

Curcumin and turmeric protect the liver against several toxicants both in vitro and in vivo. Reddy and Lokesh (1992) found that oral administration of curcumin (30mg/kg body weight) for 10 days lowered the liver and serum lipid peroxide levels, serum alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH), enhanced by i.p. injection of iron in rats. 

I nblc IV. KITccts of Curcumin on ADP plus Ascorbic Acid-induced Lipid Peroxidation in Rat Liver Mitoebndria... 

Curcumin (I), the major constituent of the spice turmeric, is a molecule of considerable interest as u consequence of its known biological activity. This includes the light-induced oxidative killing of bacteria (/,2) and aniicarcittogcnesis related to inhibition of lipid peroxidation (J-6). A.s part of a program aimed at understanding the amicarcinogenic activity of this molecule (cf. Ref. 7) we have examined the behavior of... 

Ltptd(s), generation of compounds, 54-56 Lipid level, effects of curcumin, 203-204 Lipid peroxidation, effects of curcumin, 199-205... 

A mixture of mitochondrial suspension (0.5 ml, 10 mg protein/ml), Kerbs-Ringer phosphate buffer containing 40 mM ADP, 12 mM ascorbic acid and the indicated amount of curcumin and flavone of M ciiamoniilla L. were incubated at 37° C for 15 minutes in a final volume of 1 ml. In the treatment I group, buffer contained 5 x lO M curcumin. In the treatment 2 group, buffer contained 0.45 x 10 M curcumin and 0.05 x 1 O M flavone. Lipid peroxides of mitochondria were determined by the method ofOhkawa cl al. ( 0). 

Similarly, the phenolic antioxidants p-coumaric acid, ferulic acid, curcumin, and caffeic acid, which are found in coriander (as well as members of the Labiatae family, see below), inhibit the formation of 3-nitrotyrosine in vitro and may prevent lipid peroxidation in vivo [14, 15]. Caffeic acid and other hydroxycinnamic acids have also been found to exert an inhibitory effect on LDL oxidation, a known risk factor for CHD [16]. 

Soni et al. examined the effect of curcumin on seram levels of cholesterol and hpid peroxides in 10 healthy human volunteers. A dose of 500mg of curcumin per day for 7 days significantly decreased the level of serum lipid peroxides (33%), increased HDL cholesterol (29%), and decreased total serum cholesterol (11.63%). The results suggest curcumin as a chemopreventive substance against arterial diseases. 

Soudamini, K.K., Unnikrishnan, M.C., Soni, K.B., and Kuttan, R., Inhibition of lipid peroxidation and cholesterol levels in mice by curcumin, Indian J. Physiol Pharmacol, 36 (4), 239-243,1992. 

In rat hepatocytes, the compound curcumin was cyto-protective at concentrations of 0.05 mM, whereas at 5 mM the observed protective effect on lipid peroxidation was accompanied with a tendency to increase cellular glutathione depletion and lactate dehydrogenase leakage (Donatus et al. 1990). 

A decrease in the levels of liver lipid peroxides were observed in mice administered 4 mg/kg (10% curcumin) daily of turmeric hydroalcoholic extract for 4 weeks. No toxic effects of the turmeric were observed (Miquel et al. 1995). 

The pigment mixture from turmeric is used to dye textiles (yellow to brown, cotton, wool, and silk) and to color certain foodstuffs. Curcumin is an important constituent of Indian curry spice. Curcumin inhibits lipid peroxidation and has antibacterial activity. It inhibits activation of transcription factor NFxB (relevant for signal transduction, septic shock, inflarrunatory diseases). ... 

Kaul S, Krishnakantha TP. Influence of retinol deficiency and curcumin/turmeric feeding on tissue microsomal membrane lipid peroxidation and fatty acids in rats. Mol Cell Biochem 1997 175 43 8. 

Daily administration of curcuminoids (0.5 g) to healthy human volunteers produced a 33% reduction in blood lipid peroxide levels (Soni and Kuttan 1992). This was accompanied by an increase in HDL cholesterol and a decrease in total serum cholesterol as a result of curcumin administration (500 mg/day for 7 days) (Quiles etal. 2002). The reduction in serum lipid peroxides and cholesterol suggests the potential of curcumin against arterial diseases. Supplementation with turmeric extract reduced oxidative stress and attenuated the development of atherosclerotic fatty streaks in rabbits fed on a high-cholesterol diet (Quiles etal. 2002). 

Oxidation of LDL plays an important role in the development of atherosclerosis. Turmeric extract decreased the susceptibility of LDL to lipid peroxidation, thus suggesting its value in the management of cardiovascular disease (Ramirez-Tortosa et al. 1999). In healthy hiunans, the daily intake of 200 mg of turmeric extract resulted in a decrease in total blood lipid peroxides as well as in HDL- and LDL-lipid peroxidation (Miquel et al. 2002). The beneficial influence of dietary curciunin on the susceptibility of LDL to oxidation was examined in an animal study. Dietary curcumin significantly inhibited the in vivo iron-induced LDL oxidation as well as copper-induced oxidation of LDL in vitro (Manjunatha and Srinivasan 2006). 

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