Lipid Nanoparticles

RH Muller, K Mader, S Gohla. Solid lipid nanoparticles (SLN) for controlled drug delivery-A review of the state of the art. Eur J Pharm Biopharm 50(1) 161-177, 2000. 

K Westesen, B Siekmann. Investigation of the gel formation of phospholipid-stabilized solid lipid nanoparticles. Int J Pharm 151(l) 35-45, 1997. 

The production of CLS by the melt dispersion technique is based on the melting of the lipid core material together with the lipophilic agent (i.e., phospholipids). Afterward, a warm aqueous solution is added to the molten material and is mixed by various methods (i.e., mechanical stirring, shaking, sonication, homogenization). Then the preparation is rapidly cooled until lipid solidification and the formation of particle dispersion. This method was used by Olbrich et al. [19] to produce the cationic solid lipid nanoparticles to use as novel transfection agent. 

Olbrich, C., Bakowsky, U., Lehr, C.M., Muller, R.H., and Kneuer, C., Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA, Journal of Controlled Release, 2001, 77, 345-355. 

Muller, R.H., Ruhl, D., Runge, S., Schulze-Forster, K., and Mehnert, W., Cytotoxicity of solid lipid nanoparticles as a function of the lipid matrix and the surfactant, Pharmaceutical Research, 1997, 14, 458-462. 

Yang, S.C., Zhu, J., Lu, Y., Liang, B., and Yang, C., Body distribution of camptothecin solid lipid nanoparticles after oral administration, Pharmaceutical Research, 1999, 16, 751-757. 

Muller, R.H., Maassen, S., Schwarz, C., and Mehnert, W., Solid lipid nanoparticles (SLN) as potential carrier for human use interaction with human granulocytes, Journal of Controlled Release, 1997, 47, 261-269. 

Olbrich, C. and Muller, R.H., Tabatt, K., Kaiser, O., Schulze, C., and Schade, R., Stable biocompatible adjuvants — a new type of adjuvant based on solid lipid nanoparticles a study on cytotoxicity, compatibility and efficacy in chicken, Alternatives to Laboratory Animals, 2002, 30, 443 158. 

Dingier, A., and Gohla, S., Production of solid lipid nanoparticles (SLN) scaling up feasibilities, Journal of Microencapsulation, 2002, 19, 11-16. 

Hatakeyama H, Akita H, Ito E, Hayashi Y, Oishi M, Nagasaki Y, Danev R, Nagayama K, Kaji N, Kikuchi H, Baba Y, Harashima H (2011) Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials 32 4306-4016... 

Muller, R.H., K. Mader, S. Gohla, Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery A Review of the State of the Art, European Journal of Pharmaceutics and Biopharmaceutics. 50, 161, 2000. 

Stevens PJ, Sekido M, Lee RJ. A folate receptor-targeted lipid nanoparticle formulation for a lipophilic paclitaxel prodrug. Pharm Res 2004 21 2153. 

Choi J, MacKay J, Szoka F. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles preparation and characterization. Bioconj Chem 2003 14 420. 

Delivery of Lipophilic Compounds with Lipid Nanoparticles... 

FIGURE 7.3 Models of drug incorporation into solid lipid nanoparticles. 

Muller, R. H., et al., Sohd lipid nanoparticles (SLN) an alternative colloidal drug carrier system for controlled drug debvery. Eur. J. Pharm. Biopharm., 41, 1995. 

Muller, R. H., Radtke, M. and Wissing, S. A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev., 54 (Snppl. 1), S131-55, 2002. 

Ahlin, P., Kristi, J. and Smid-Kobar, J., Optimization of procedure parameters and physical stabdity of solid lipid nanoparticles in dispersions. Acta Pharm., 48, 257-67, 1998. 

Unruh, T., et al., Observation of size-dependent melting in lipid nanoparticles. J. Phys. Chem. B, 103, 10373-77, 1999. 

Jenning, V, Mader, K. and Gohla, S. H., Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids a H-NMR study. Int. J. Pharm., 205, 15-21, 2000. 

Freitas, C. and Muller, R. H., Stability determination of solid lipid nanoparticles (SEN) in aqueous dispersion after addition of electrolyte. J. MicroencapsuL, 16, 59-71, 1999. Bunjes, H., Westesen, K. and Koch, M. H. J., Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int. J. Pharm., 129, 159-73, 1996. Freitas, C. and Muller, R. H., Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. Eur. J. Pharm. Biopharm., 47, 125-32, 1999. 

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