Solid lipid nanoparticles drug loading

Jenning, V., et al., Vitamin A loaded solid lipid nanoparticles for topical use occlusive properties and drug targeting to the upper skin. Eur. J. Pharm. Biopharm., 49, 211-18, 2000. 

In spite of a rapidly increasing amount of literature data on drug-loaded solid lipid nanoparticle dispersions, there is comparatively little systematic knowledge about the interaction of drugs with these complex systems (e.g., with respect to the state and localization of the drug within the dispersions). One reason may be that the type of interaction is expected to be quite specific for each drug/particle matrix combination, and this interaction may also depend on the general composition of the dispersion and the preparation procedure. 

Schwarz C. and Mehnert W, Freeze-drying of drug-free and drug-loaded solid lipid nanoparticles, Int. J. Pharm., 157, 171, 1997. 

Incorporation of the steroidal drugs hydrocortisone and progesterone in complex with p-CD and HP-P-CD reduced the particle size for solid lipid nanoparticles (SLNs) below lOOnm. Steroids were demonstrated to be dispersed in the amorphous state. Compexation to CDs resulted in higher drug-loading properties for the more hydrophobic drug hydrocortisone and lower in vitro release for both drugs when they are complexed to CDs rather than their free form [31]. 

Schwarz, C. and Mehnert, W. (1995) Sterilization of drug-free and tetracaine-loaded solid lipid nanoparticles (SLN). Proc. First World Meeting APGI/APV, Budapest, 485 186. 

Schwarz, C., Freitas, C., Mehnert, W. and Muller, R.H. (1995) Sterilization and physical stability of drug-free and etomidate-loaded solid lipid nanoparticles. Proc. Int. Symp. Control. Rel. Bioct. Mater. 22, 766-767. 

E. Peira, et ah. In vitro and in vivo study of solid lipid nanoparticles loaded with superparamagnetic iron oxide, J. Drug Target 11 (1) (2003) 19-24. 

Hwang YJ et al (2005) Controlled release of retinol from silica particles prepared in OAV/0 emulsion the effects of surfactants and polymers. J Control Release 106 339-349 Jenning V et al (2000) Vitamin A loaded solid lipid nanoparticles for topical use drug release properties. J Control Release 66 115-126 Joiner A (2004) Tooth colour a review of the literature. J Dent 32 3-12 Joiner A (2006) The bleaching of teeth a review of the literature. J Dent 34 412—419 Kim DG et al (2006) Retinol-encapsulated low molecular water-soluble chitosan nanoparticles. Int JPharm 319 130-138... 

The phenomenon of expulsion and adherence of excess drug in a liquid supercooled state on the surface of solid lipid nanoparticles at higher drug load was already described by Bunjes et al. on tripalmitin nanoparticles loaded with ubidecarenone. ... 

Wang F, et al. Methazolamide-loaded solid lipid nanoparticles modified with low-molecular weight chitosan for the treatment of glaucoma vitro and vivo study. J Drug Target 2014 22(9) 849-58. 

S. Das, W. Kiong Ng, R.B.H. Tan, Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers I. Effect of formulation variables on the physicochemical properties, drug release and stability of clotrimazole-loaded nanoparticles. Nanotechnology 25 (2014) 105101 -105115. 

A. Nagi, R. Abdullah, S. Ibrahim, A. Bustamam, Tamoxifen drug loading solid lipid nanoparticles prepared by hot high pressure homogenization techniques. Am. J. Pharmacol. Toxicol. 3 (2008) 219-224. 

The solid — and normally crystalline — state of the matrix lipid has, however, some drawbacks. Due to the high order of the crystal lattice, the capacity of drug incorporation is comparatively low. ° To improve the drug loading capacity and — potentially — to obtain a sustained release of incorporated drugs, lipid nanoparticles with a modified lipid matrix were developed in recent years. As the methods for preparation and characterization... 

The incorporation of lecithin in different amounts (10-50% related to the triglyceride) did not influence the melting or crystallization temperature of the hard fat in the bulk phase neither in the nanoparticles but led to an accelerated polymorphic transition to the stable 6-modification particularly in the nanoparticles. No additional colloidal structures derived from the emulsifiers (lecithin and Solutol) could be detected in the aqueous phase by electron microscopy and the results of H- and P-NMR studies indicate that lecithin and Solutol are nearly completely attached to the particle surface. However, from the results it was also concluded that due to the redistribution of the lecithin from the lipid matrix and its enrichment in the particle interface, neither an increase in drug load (into the solid... 

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