Solid lipid nanoparticles SLN

RH Muller, K Mader, S Gohla. Solid lipid nanoparticles (SLN) for controlled drug delivery-A review of the state of the art. Eur J Pharm Biopharm 50(1) 161-177, 2000. 

Muller, R.H., Maassen, S., Schwarz, C., and Mehnert, W., Solid lipid nanoparticles (SLN) as potential carrier for human use interaction with human granulocytes, Journal of Controlled Release, 1997, 47, 261-269. 

Dingier, A., and Gohla, S., Production of solid lipid nanoparticles (SLN) scaling up feasibilities, Journal of Microencapsulation, 2002, 19, 11-16. 

Muller, R.H., K. Mader, S. Gohla, Solid Lipid Nanoparticles (SLN) for Controlled Drug Delivery A Review of the State of the Art, European Journal of Pharmaceutics and Biopharmaceutics. 50, 161, 2000. 

Muller, R. H., Radtke, M. and Wissing, S. A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev., 54 (Snppl. 1), S131-55, 2002. 

Jenning, V, Mader, K. and Gohla, S. H., Solid lipid nanoparticles (SLN) based on binary mixtures of liquid and solid lipids a H-NMR study. Int. J. Pharm., 205, 15-21, 2000. 

Freitas, C. and Muller, R. H., Stability determination of solid lipid nanoparticles (SEN) in aqueous dispersion after addition of electrolyte. J. MicroencapsuL, 16, 59-71, 1999. Bunjes, H., Westesen, K. and Koch, M. H. J., Crystallization tendency and polymorphic transitions in triglyceride nanoparticles. Int. J. Pharm., 129, 159-73, 1996. Freitas, C. and Muller, R. H., Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase. Eur. J. Pharm. Biopharm., 47, 125-32, 1999. 

A novel sunscreen system based on tocopherol acetate incorporated into solid lipid nanoparticles has been developed. In recent years, solid lipid nanoparticles (SLN) have been introduced as a novel carrier system for drugs and cosmetics. It has been found that SLN possess characteristics of physical UV-blockers on their own, thus offering the possibility of developing a more effective sunscreen system... 

Cavalli R. et al., The effect of the components of microemulsions on both size and crystalline structure of solid lipid nanoparticles (SLN) containing a series of model molecules, Pharmazie, 53, 392, 1998. 

Dingier A. et al.. Solid lipid nanoparticles (SLN/Lipopearls) a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products, J. Microencapsulation, 16, 751, 1999. 

Fundaro A. et al.. Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin pharmacokinetics and tissue distribution after i.v. administration to rats,... 

Solid-Lipid Nanoparticles SLNs have been used to deliver small molecules and macromolecules such as DNA and peptides. The in vitro and in vivo applications of SLNs are reviewed elsewhere [125,126]. The stability and oral bioavailability of insulin were enhanced when administered in wheat germ agglutinin-conjugated nanoparticles [127], A polyoxyethylene stearate coat on the SLN confers stealth properties [128],... 

Freitas, C., and Muller, R. H. (1999), Correlation between long-term stability of solid lipid nanoparticles (SLN) and crystallinity of the lipid phase, Eur. J. Pharm. Biopharm., 47(2), 125-132. 

Incorporation of the steroidal drugs hydrocortisone and progesterone in complex with p-CD and HP-P-CD reduced the particle size for solid lipid nanoparticles (SLNs) below lOOnm. Steroids were demonstrated to be dispersed in the amorphous state. Compexation to CDs resulted in higher drug-loading properties for the more hydrophobic drug hydrocortisone and lower in vitro release for both drugs when they are complexed to CDs rather than their free form [31]. 

Pinto, J.F. Muller, R.H. Pellets as carriers of solid lipid nanoparticles (SLN) for oral administration of drugs. Pharmazie 1999, 54 (7), 506-509. 

Muller, R.H. Mehnert, W. Lucks, J.-S. Schwarz, C. Muhlen, A. Weyhers, H. Ereitas, C. Ruhl, D. Solid lipid nanoparticles (SLN)—an alternative colloidal carrier system for controlled drug delivery. Eur. J. Pharm. Biopharm. 1995, 41 ( ), 62-69. 

Oil and water [oil-in-water (0/W) or water-in-oil (W/0)] emulsions are utilized for the production of nanoparticle dispersions. The colloidal emulsions are stabilized by a film of surfactants and polymers, which interact with the oil and water phases to prevent aggregation and droplet growth. These microemulsions are typically used as templates for the production of nanoparticles and solid lipid nanoparticles (SLN). 

Almeida, A.J., Runge, S. and Muller, R.H., Peptide-loaded solid lipid nanoparticles (SLN) influence of production parameters, International Journal of Pharmaceutics, 2001, 149, 255-265. 

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