Nanostructured lipid carriers

Muller, R. H., Radtke, M. and Wissing, S. A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev., 54 (Snppl. 1), S131-55, 2002. 

The particle sizing by field flow fractionation (FFF) is based on the different effect of a perpendicular applied field on particles in a laminar flow [63-66], The separation principle corresponds to the nature of the perpendicular field and may, for example, be based on different mass (sedimentation FFF), size (cross-flow FFF), or charge (electric-field FFF). Cross-flow FFF has been applied recently to investigate nanoemulsions, SLN, and nanostructured lipid carriers (NLC, particles composed of liquid and solid lipids) [58], Although all samples had comparable particle sizes in PCS, their retention in the FFF was very different. Compared to the spherical droplets of the nanoemulsion, SLN and NLC were pushed more efficiently to the bottom of the channel because of their anisotropic shape. Their very different shapes have been confirmed by electron microscopy. 

Liu L, Tang Y, Gao C, Li Y, Chen S, Xiong T et al. Characterization and biodistribution in vivo of quercetin-loaded cationic nanostructured lipid carriers. Colloids SurfB Biointerfaces. 2014 115 125-131. 

Nanostructure lipid carriers indicate lipid particles with a disperse phase made of a mixture of solid and liquid lipids. Owing to the decreased melting point of the lipid phase, such systems can be produced at lower temperatures, reducing the extent of degradation of the thermolabile compounds. "... 

Iqbal, M. A. Md, S. Sahni, J. K. Baboota, S. Dang, S. All, J., Nanostructured lipid carriers system Recent advances in drug delivery. Journal of Drug Targeting (2012) 20, 813-830. 

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers.1154... 

SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS... 

Pardeike, J., Weber, S., Haber, T., Wagner, J., Zarfl, H., Plank, H., Zimmer, A. Development of an Itraconazole-loaded nanostructured lipid carrier (NLC) formulation for pulmonary application. Int. J. Pharm. 2011, 419 (1-2), 329-338. 

Das, S., Ng, W.K., Tan, R.B. Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs) Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs Eur. J. Pharm. Sci. 2012, 47 (1), 139-151. 

Gokce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O. Resveratrol-loaded soUd lipid nanoparticles versus nanostructured lipid carriers evaluation of antioxidant potential for dermal applications. Interrmtional Journal of Nanomedicine. 2012 7 1841. 

Nanostructured lipid carriers (NLC) were introduced as the second generation of For the preparation of... 

Due to their positive influence on skin hydration and viscoelasticity ° ° as well as their UV-blocking potential, solid lipid nanoparticles and the related nanostructured lipid carriers appear very promising for cosmetics and first cosmetics based on SEN are commercial available. Eipid nanoparticle based formulations were e.g. developed for anti-ageing and sunscreen formulations. As cosmetics shall be active solely on the skin, the permeation of components of the formulations through the skin is undesirable because of potential adverse systemic effects. 

S. Das, W. Kiong Ng, R.B.H. Tan, Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers I. Effect of formulation variables on the physicochemical properties, drug release and stability of clotrimazole-loaded nanoparticles. Nanotechnology 25 (2014) 105101 -105115. 

M. Fathi, J. Varshosaz, M. Mohebbi, F. Shahidi, Hesperetin-loaded solid lipid nanoparticles and nanostructure lipid carriers for food fortification Preparation, characterization, and modeling. Food Process Biotechnol. 6 (2013) 1464-1475. 

F.Q. Hu, S.P. Jiang, Y.Z. Du, H. Yuan, Y.Q. Ye, S. Zeng, Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system. Colloids Surf., B. 45 (2005) 167-173. 

R.M. Khalil, A. Abd-Elbary, M.A. Kassem, M.M. Ghorab, M. Basha, Nanostructured lipid carriers (NLCs) versus solid lipid nanoparticles (SLNs) for topical delivery of meloxicam, Pharm. Dev. Technol. 19 (2014) 304-314. 

A. Chinsriwongkul, P. Chareanputtakhun, T. Ngawhirunpat, T. Rojanarata, W. Sila-on, U. Ruktanonchai, P. Opanasopit, Nanostructured lipid carriers (NLC) for parenteral delivery of an anticancer drug, AAPS Pharm. Sci. Tech. 13 (2011) 150-158. 

Y.C. Kuo, J.F. Chung, Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers. Colloids Surf, B. 83 (2011) 299-300. 

J. Varshosaz, S. Eskandari, M. Tabakhian, Production and optimization of valproic acid nanostructured lipid carriers by the Taguchi design, Pharm. Dev. Technol. 15 (2010) 89-96. 

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