Polymer lipid hybrid nanoparticles

New functions can be obtained by modifications of SLNs. Incorporation of Tween 80 and Poloxamer 188 can stabilize SLNs to achieve long-circulating or crossing blood-brain barrier effects [112], Recently, novel nanoparticles called polymer-lipid hybrid nanoparticles (PLNs) were developed [113]. They can entrap cationic anticancer agents (e.g., doxorubicin) effectively by incorporation of an anionic lipophilic polymer into lipids to treat multidrug-resistant (MDR) cancers. 

Wong, H. L., Bendayan, R., Rauth, A. M., and Wu, X. Y. (2006), Simultaneous delivery of doxorubicin and GG918 (Elacridar) by new polymer-lipid hybrid nanoparticles (PLN) for enhanced treatment of multidrug-resistant breast cancer, J. Controlled... 

Wong, H.L. A.M. Rauth R. Bendayan J.L. Manias M. Ramaswamy Z. Liu S.Z. Erhan X.Y. Wu. A new polymer-lipid hybrid nanoparticle system increases cytotoxicity of doxorubicin against multidrug-resistant human breast cancer cells. Pharm. Res. 2006, 23, 1574—1585. 

BBS, blood-brain barrier LDL, low-density lipoprotein PLN, polymer-lipid hybrid nanoparticles SLN, solid lipid nanoparticles. 

Wong HL, Rauth AM, Bendayan R, Wu XY. Combinational treatment with doxorubicin and GG918 (Elacridar) using polymer-lipid hybrid nanoparticles (PLN) and evaluation of strategies for multidrug-resistance reversal in human breast cancer cells. 

Wong HL, Bendayan R, Rauth AM, Xue HY, Babakhanian K, WuXY. Amechanistic study of enhanced doxorubicin uptake and retention in multidrug resistant breast cancer cells using a polymer-lipid hybrid nanoparticle (PLN) system. J Pharmacol Exp Ther 2006 317 1372-1381. 

WongHL, Rauth AM, Bendayan R, WuXY. Evaluation of the in vivo efficacy, toxicity and lymphatic drainage of loco-regional administered polymer-lipid hybrid nanoparticles (PEN) loaded with doxorubicin in a murine solid tumor model. Eur J Pharm Biopharm 2007 65 300-308. 

Wong, H., Rauth, A.M., Bendayan, R., Wu, X.Y. In vivo evaluation of a new polymer-lipid hybrid nanoparticle (PEN) formulation of doxorubicin in a murine solid tumor model. Eur. J. Pharm. Biopharm. 

Kumbhar, D. and V. Pokharkar. Physicochemical investigations on an engineered lipid-polymer hybrid nanoparticle containing a model hydrophilic active, zidovudine. Colloid Surface A, 436 (2013) 714—725. 

Farokhzad et al. reported the immnnological characterization of lipid-polymer hybrid nanoparticles and proposed a method to control the levels of complement activation induced by these nanoparticles. In this method, the nanoparticle snrface was modified by attaching methoxyl, carboxyl, and amine groups. It was found that the snrface chemistry significantly affects human plasma and serum protein adsorption patterns. ... 

Wang, Y., Kho, K., Cheow, W.S., Hadinoto, K. A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles. Int. J. Pharm. 2012, 424 (1-2), 98-106. 

Salvador-Morales, C., Zhang, L., Langer, R., Farokhzad, O. Immunocompatibility properties of lipid-polymer hybrid nanoparticles with heterogeneous surface functional groups. Biomaterials 2009, 30 (12), 2231-2240. 

Zhang, L.F., Chan, J.M., Gu, F.X., Rhee, J.W., Wang, A.Z., Radovic-Moreno, A.F., Alexis, F., Langer, R., Farokhzad, O.C. Self-assembled lipid-polymer hybrid nanoparticles A robust drug delivery platform. ACS Nano. 2(8), 1696-1702 (2008). doi 10.1021/Nn800275r... 

Recently, the production and use of lipoprotein biomimetic particles, as for example thermosensitive liposomes loaded with diagnostically or therapeutically active compounds in their core or lipid-polymer hybrid nanoparticles as a new generation therapeutic deliveiy platform, as well as liposomes usable for MRI-guided drug deliveiy, was reviewed. 

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