Nanoparticles/nanostructures lipid

Muller, R. H., Radtke, M. and Wissing, S. A., Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations. Adv. Drug Deliv. Rev., 54 (Snppl. 1), S131-55, 2002. 

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers.1154... 

SOLID LIPID NANOPARTICLES AND NANOSTRUCTURED LIPID CARRIERS... 

Das, S., Ng, W.K., Tan, R.B. Are nanostructured lipid carriers (NLCs) better than solid lipid nanoparticles (SLNs) Development, characterizations and comparative evaluations of clotrimazole-loaded SLNs and NLCs Eur. J. Pharm. Sci. 2012, 47 (1), 139-151. 

Gokce EH, Korkmaz E, Dellera E, Sandri G, Bonferoni MC, Ozer O. Resveratrol-loaded soUd lipid nanoparticles versus nanostructured lipid carriers evaluation of antioxidant potential for dermal applications. Interrmtional Journal of Nanomedicine. 2012 7 1841. 

From these studies the postulated advantages (higher drug load in the matrix lipid core compared to SLN and retarded drug release compared to fat emulsions) of this kind of nanostructured lipid nanoparticles cannot be expected for the formulations studied (e.g. glyceryl behenate/medium chain triglycerides mixtures). 

Due to their positive influence on skin hydration and viscoelasticity ° ° as well as their UV-blocking potential, solid lipid nanoparticles and the related nanostructured lipid carriers appear very promising for cosmetics and first cosmetics based on SEN are commercial available. Eipid nanoparticle based formulations were e.g. developed for anti-ageing and sunscreen formulations. As cosmetics shall be active solely on the skin, the permeation of components of the formulations through the skin is undesirable because of potential adverse systemic effects. 

S. Das, W. Kiong Ng, R.B.H. Tan, Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers I. Effect of formulation variables on the physicochemical properties, drug release and stability of clotrimazole-loaded nanoparticles. Nanotechnology 25 (2014) 105101 -105115. 

M. Fathi, J. Varshosaz, M. Mohebbi, F. Shahidi, Hesperetin-loaded solid lipid nanoparticles and nanostructure lipid carriers for food fortification Preparation, characterization, and modeling. Food Process Biotechnol. 6 (2013) 1464-1475. 

R.M. Khalil, A. Abd-Elbary, M.A. Kassem, M.M. Ghorab, M. Basha, Nanostructured lipid carriers (NLCs) versus solid lipid nanoparticles (SLNs) for topical delivery of meloxicam, Pharm. Dev. Technol. 19 (2014) 304-314. 

Y.C. Kuo, J.F. Chung, Physicochemical properties of nevirapine-loaded solid lipid nanoparticles and nanostructured lipid carriers. Colloids Surf, B. 83 (2011) 299-300. 

The most significant dosage forms are liposomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and self-emulsilying drug-delivery systems (SEDDS). 

Weber S, Zimmer A, Pardeike J. Solid lipid nanoparticles (SLN) and nanostructured Upid carriers (NEC) for pulmonary application A review of the state of the art. European Journal of Pharmaceutics and Biopharmaceutics. 2014 86(l) 7-22. 

Chitosan has been investigated as a coating agent for novel formulations such as liposomes and solid lipid nanoparticles. The coating of chitosan on nanostructured systems increases the drug bioavailability owing to its permeation enhancement properties [166,167]. 

For example, by using the nanostructure-initiator mass spectrometry, Patti and colleagues [130] detected intact cholesterol and its derivative molecules in situ to provide the first images of brain sterol localization in a knockout mouse model of 7-dehydrocholesterol reductase. Other nanomaterials (e.g silver nanoparticles) have also been used to analyze lipids directly from tissue samples [133], From a thin film of colloidal graphite on rat brain tissue, direct lipid profiling was performed by graphite-assisted laser desorption/ionization mass spectrometry, which allowed to detect 22 HexCer species, whereas only eight HexCer species are detected with MALDI-TOF/MS [132], Chemically selective analysis for HexCer and ST species was successfully obtained. 

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