Solid lipid nanoparticles advantages

Solid lipid nanoparticles (SLN) SLN combine the advantages of traditional particulate drag carriers, but simultaneously avoid some of their major disadvantages. Like polymeric particles, they provide a modification of the release profile due to the solid state of the particle matrix and chemical stabilization - that is, the protection of drags incorporated into the soHd... 

High expectations were connected with this novel drug delivery system in the assumption that solid lipid nanoparticles may just combine the advantages of colloidal fat emulsions (biocompatibility, ease of preparation, avoidance of the use of organic solvents) and those of e.g. polymeric nanoparticles (solid state of the matrix). Due to the solid state of the nanoparticles, a sustained or even controlled drug release was expected. Over the years, SLN attained more and more interest in the scientific community all over the world as documented in the considerable number of research papers, review articles and book chapters in this field [e.g. Refs. 27-29]. Recently, a special issue oi Advanced Drug Delivery Reviews, Volume 59,2007 focused on this carrier system. 

Another problem in particle size determinations is that the diameter describes the size of a particle only exactly when the particle has an absolutely spherical shape that is normally not the case for solid lipid nanoparticles. Furthermore different diameters are obtained by different sizing methods (e.g. hydrod)mamic diameter by PCS). A comprehensive overview about the different particle size methods as well as advantages and limitations of the different methods was given by Washington. ... 

As the main suggested advantages of SLN over other lipidic colloidal carriers (e.g. controlled release, higher stability) are related to the solid state of the matrix lipid, physicochemical studies of the nanoparticles are crucial particularly for new compositions (e.g. lipid mixtures). 

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