Solid lipid nanoparticles evaporation

Marengo, E., Cavalli, R., Rovero, G. and Gasco, M.R. (2003) Scale-up and optimization of an evaporative drying process applied to aqueous dispersions of solid lipid nanoparticles. Pharm. Dev. Technol. 8(3), 299-309. 

In solvent evaporation method, the lipid is dissolved in a volatile organic solvent (e.g., cyclohexane or chloroform), which is dispersed in an aqueous phase to form an emulsion (Figure 58.5c). The lipid precipitates with the evaporation of the solvent and forms nanoparticle dispersion. The solid lipid nanoparticles are harvested after complete evaporation of the solvent. ... 

Liu D, Jiang S, Shen H, Qin S, Liu J, Zhang Q et al. Diclofenac sodium-loaded solid lipid nanoparticles prepared by emulsion/solvent evaporation method. Journal of Nanoparticle Research. 2011 13(6) 2375-2386. 

The solvent emulsification/evaporation method involves lipid precipitation in O/W emulsions. Solid lipids are dissolved in a water-immiscible organic solvent (e.g., cyclohexane) followed by emulsification in an aqueous medium. Upon evaporation of the solvent, the nanoparticle dispersion is formed due to lipid precipitation. Residue of organic solvents is the major problem of this method [94], However, the microemulsion and solvent emulsification/evaporation methods can be performed conveniently in the laboratory without specific apparatuses. 

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