Lesion temporal

The safety and activity of subcutaneous GM-CSF (300 micrograms/day for 1 week and 150 micrograms twice weekly for 11 weeks) has been compared with no treatment in 244 leukopenic HIV-infected patients (62). Adverse effects were reported in most of the patients treated with GM-CSF and consisted of flu-like symptoms (98%), bone pain (42%), and injection site reactions (85%). There was a two-fold increase in serum transaminase and alkaline phosphatase activities in 5.7% of patients. There was a moderate, but not significant, increase in HIV p24 antigen concentration. The few relevant clinical trials have provided no convincing evidence that GM-CSF enhances HIV replication or accelerates HIV-associated diseases (for example infections or neoplasms) in patients with AIDS (63). Only one patient with AIDS and ultrasonographic confirmation of enhanced Kaposi s sarcoma lesions temporally related to GM-CSF used for interferon- and zidovudine-related severe neutropenia has been reported (SEDA-19, 343). 

Folliculitis caused by colonization with S. aureus or S. epidermidis on the face can be sometimes misdiagnosed as acne. The prominent lesions are superficial follicular pustules that are often distributed on the lateral cheeks, the chin and the temporal sites of the forehead. The rare folliculitis due to Candida may also present as multiple pustular eruptions. 

The stimulation method could not address the role of the elaboration areas and the study of brain damaged patients or lesion studies of animals is hampered by the lack of temporal resolution. What is needed for another wave of reverse engineering, then, is the ability to stimulate the brain while it is doing something, or to be able to reversibly disrupt its functioning to give the lesion method a temporal dimension. The story of how we are able to achieve both of these takes us back to Faraday.. . . ... 

Complex partial seizures manifest themselves as bizarre behaviours which are also known as psychomotor or temporal lobe epilepsy, since a lesion (focus) is often found in that brain area. Repetitive and apparently purposeful movements vary from simple hand clenching or rubbing to more bizarre hand movements and walking. These can last a few minutes, often disrupt other ongoing activity or speech and the patient has no subsequent memory of them. Complex seizures may develop from simple ones. 

The posterior multimodal association area is located at the junction of the parietal, temporal, and occipital lobes. It pools and integrates somatic, auditory, and visual stimuli for complex perceptual processing. As such, this area is involved primarily with visuospatial localization, language, and attention. Lesions here interfere with awareness of one s body position and of the space in which it moves as well as the ability to integrate and make sense of elements of a visual scene. In other words, these patients have normal visual acuity but cannot focus on an object of interest. 

H. M. was the first human case in which specific amnesia could be linked to selective regions of the brain. Since then, many patients have been identified as having selective lesions to the temporal lobe system, especially within the hippocampus. They have exhibited amnesias similar to H. M. s. For example, amnesic patient, R. B, who had a specific lesion in the CA1 region of hippocampus, showed profound loss of ability to form new memories of people, places, and events [5]. R. B. also lost memories regarding public and personal events that he had experienced two... 

Zola-Morgan, S, Squire, L. R. and Amaral, D. Human amnesia and the medial temporal region Enduring memory impairment following a bilateral lesion limited to the CA1 field of the hippocampus. /. Neuroscience 6 2950-2967, 1986. 

Brain imaging (preferably MRI) to look for evidence of structural damage is essential after TBI. MRI, while more expensive and time-consuming, can sometimes detect small brain lesions that are missed by CT, especially in the frontal and temporal lobes that are common sources of psychiatric complications after TBI. In addition, an electroencephalogram (EEG) can detect seizure activity or other signs of abnormal brain function. Although they are not yet part of the routine post-TBI evaluation, the so-called functional brain imaging techniques such as positron emis-... 

Historically, lesions (often due to accident or tumor), trauma history, and findings on neurological exam or neuropsychological testing have furnished evidence regarding localization. Two regions have most consistently been implicated the prefrontal cortex and temporal lobe. 

Cushman, K. E., Tibbitts, T. W., Sharkey, T. D., Wise, R. R. (1995). Constant-light injury of potato Temporal and spatial patterns of carbon dioxide assimilation, starch content, chloroplast integrity, and necrotic lesions. J. Amer. Soc. Hort. Sci., 120,1032-1040. 

Anterior temporal lobe lesions Diseases of the spinal cord Loss of sensory input Tabes dorsalis... 

In inferior MCA trunk occlusion infarctions of the lateral surface of the temporal lobe and the inferior parietal lobe may occur (Olsen 1991 Ringelstein et al. 1992). Motor or sensory deficits may not be severe, but visual field deficit and sensory aphasia in left sided infarctions and constructional apraxia in right sided lesions occur (Geschwind 1975 Spinazzola et al. 2003). Right temporal lesions cause agitation and confusion resembling an organic psychosis (Ferro 2001). 

The insight into the dynamic nature of ischemic brain lesions has raised growing attention over the past few years. Distinct temporal and spatial patterns of lesion evolution have been described for two types of cerebral ischemia that differ in many pathophysiological aspects namely conditions of focal and global cerebral ischemia. 

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