And brain lesions

Wall, H.G., N.K. Jaax and I.J. Hayward. 1990. Motor activity and brain lesions in soman intoxicated rhesus monkeys. Proc. of the Workshop on Convulsions and Related Brain Damage Induced by Organophosphorous Agents, ADA222912, Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, pp. 21-29. (cited in Baze, 1993)... 

BSE is not transmissible to humans. However, there appears to be a strong connection between BSE and a variation of Creutzfeldt-Jakob disease, known as variant Creutzfeldt-Jakob disease (vCJD), another disease grouped with other TSEs. Evidence to date indicates that there has never been a case of vCJD transmission from person to person, but rather it is thought to spread from the consumption of cattle products contaminated with BSE. BSE and vCJD share many characteristics, to the point of being nearly indistinguishable from each other. Clinical studies have shown that mice inoculated with BSE showed the same pattern of incubation time, clinical signs, and brain lesions as mice inoculated with tissues from patients with vCJD. This provides evidence that BSE and vCJD are of the same strain . Furthermore, these two diseases were not similar to other TSEs such as sporadic CJD and known scrapies strains. 

Figure 5. Correlation between regional water content and regional cerebral blood flow in cerebral edema adjacent to brain tumors and brain lesions...

Diazepam, an anticonvulsant of the benzodiazepine family, has been shown to control soman-induced convulsions in monkeys96 and convulsions induced by other ChE inhibitors in the rabbit.97,98 There have also been anecdotal reports of its effectiveness in controlling convulsions induced by organophosphate insecticides. In rats, diazepam has been reported to decrease the frequency of convulsions and brain lesions (although, when given without atropine, it did not decrease mortality).99 When given with 2-PAM Cl, with or without atropine, diazepam reduced the severity, but not the incidence, of brain lesions in soman-poisoned rats.100... 

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