Kraus studies

M Krause. Studies on the biosynthesis of the cyclooctadepsipeptide PF10022A. Ph.D. thesis, Technische Universitat Berlin, Berlin, 1998. 

Thanks are due to Dr. Setinek for his cooperation in this field, to the late Prof. Baiant for his interest and encouragement in the work, and to Dr. Kraus for stimulating discussions in the course of these studies and during the preparation of the article as well as for critical reading of the manuscript. 

Staudt and Krause commented in 1998, based on the results of a study by the Institut fiir Angewandte Innovationsforschung, Bochum (Institute for Applied Innovation Research), that many micro-systems technical companies stiU have prob-... 

Hereditary deficiency of phosphoglycerate kinase (PGK) is associated with hereditary hemolytic anemia and often with central nervous system dysfunction and/or myopathy. The first case, reported by Kraus et al. (K24), is a heterozygous female, and the results are not so clear. The second family, reported by Valentine et al. (V3), is a large Chinese family, whose pedigree study indicates that PGK deficiency is compatible with X-linked inheritance. To date, 22 families have been reported (04, T25, Y3). Nine of these have manifested both symptoms five have shown only hemolysis seven have shown the central nervous system dysfunction and/or myopathy but without hemolysis and one case, PGK Munchen, is without clinical symptoms (F5). PGK II is an electrophoretic variant found in New Guinea populations (Y2). Red blood cell enzyme activity, specific activity, and the kinetic properties of this polymorphic variant are normal. 

Englert N, Krause C, Thron H-L, et al. 1987. Studies on lead exposure of selected population groups in West Berlin, West Germany. Trace Elem Med 4 112-116. 

R, Runzi M, Kron M, Kahl S, Kraus D, Jung N, Maier L, Malfertheiner P, Goebell H, Beger HG German Antibiotics in Severe Acute Pancreatitis Study Group Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis A placebo-con-trolled, double-blind trial. Gastroenterology 2004 126 997-1004. 

Ursing B, Aim T, Barany F, Bergelin I, Ganrot-Norlin K, Hoevels J, Huitfeldt B, Jarnerot G, Krause U, Krook A, Lindstrom B, Nordle O, Rosen A A comparative study of metronidazole and sulfasalazine for active Crohn s disease The cooperative Crohn s disease study in Sweden. II. Result. Gastroenterology I982 83 550-562. 

Krause RT. 1973. Detemiination of several chlorinated pesticides by the AOAC multiresidue method with additional quantitation of perthane after dehydrochlorination Collaborative study. J Assoc Off Anal Chern 56(3)721-727. 

Krause, K. A., and G. E. Moore Anion Exchange Studies. I. Separation... 

Kraus, C. A., and C. L. Brown Studies relating to organogermanium deri-... 

U. Kertscher, M. Beyermann, E. Krause, J. Furkert, H. Berger, M. Bienert, B. Mehlis, The Degradation of Corticotropin-Releasing Factor by Enzymes of the Rat Brain Studied by Liquid Chromatography-Mass Spectrometry , Peptides 1998, 19, 649-658. 

The role of PARP-1 as a modulator of chromatin stiucture, as well as its chromatin-dependent effects on transcription, has been well established in the literature (D Amours et al, 1999 Kraus and Lis, 2003 Rouleau et al, 2004 Kim et al, 2005). In this section, we will highlight some of the historical studies, as well as more recent studies, that have characterized the role of PARP-1 and PAR in these processes. Note that, when describing this work, the term PARP in the absence of any additional identifiers refers to PAR-generating proteins of ambiguous identity (e.g., as in early studies, which were conducted without the knowledge that multiple PARP family members exist, or when multiple splice variants of a PARP-1-like protein exist in a single organism, as in Drosophila). 

A similar system, (CH3)2C=CH X, was studied by Endrysova and Kraus (55) in the gas phase in order to eliminate the possible leveling influence of a solvent. The rate data were separated in the contribution of the rate constant and of the adsorption coefficient, but both parameters showed no influence of the X substituents (series 61). A definitive answer to the problem has been published by Kieboom and van Bekum (59), who measured the hydrogenation rate of substituted 2-phenyl-3-methyl-2-butenes and substituted 3,4-dihydro-1,2-dimethylnaphtalenes on palladium in basic, neutral, and acidic media (series 62 and 63). These compounds enabled them to correlate the rate data by means of the Hammett equation and thus eliminate the troublesome steric effects. Using a series of substituents with large differences in polarity, they found relatively small electronic effects on both the rate constant and adsorption coefficient. 

Zdrazil and Kraus (727) studied the related hydrogenolysis of 24 esters R COOR, where R and R were alkyl groups (series 100). The catalyst was rhodium, and the temperature was 300°C. The relative reactivities of the esters could be correlated by a modified Taft equation... 

M. W. Roberts reviews the contribution of photoelectron spectroscopy to provide chemical information at the molecular level to the catalytic reactions on surfaces. The use of organic probes to study the rate-determining steps and mechanisms of catalytic reactions is reviewed by R. W. Maatman and M. Kraus, respectively. 

Other functional imaging studies of the DA system have reported decreased Di receptor density (Dagher et al. 2001), increased F-DOPA uptake (a marker for increased DA turnover) (Salokangas et al. 2000), and both decreased (Krause et al. 2002) and no alterations (Staley et al. 2001) in dopamine transporter binding in smokers. 

Krause et al. challenged this assignment of the F Is signal. " In their XPS study of Al cycled in electrolytes based on Lilm, LiBeti, and LiPFe, they also observed this F signal that is typical of metal fluoride, but they believed that LiF instead of AIF3 would be responsible for it because of the detection of Li and the relative abundance of these two elements. Carbonate species as indicated by both C Is and 0 1s spectra were also present, which may exist in the forms of either Al2(C03)3 or Li2C03. Thus, the authors postulated that oxidation of solvent also... 

Krause DS, Reinhardt J, Vazquez JA, Reboli A, Goldstein BP, Wible M, Henkel T. (2004) Phase 2, randomized, dose-ranging study evaluating the safety and efficacy of anidulafungin in invasive candidiasis and candidemia. Antimicrob Agents Chemother 48 2021-2024. 

M. Souvatzoglou, A.L. Grosu, B. Roper, B.J. Krause, R. Beck, G. Reischl, M. Picchio, H.J. Machulla, H.J. Wester, M. Piert, Tumor hypoxia imaging with [18F] FAZAPET in head and neck cancer patients A pilot study, Eur. J. Nucl. Med. Mol. Imaging 34(10) (2007) 1566-1575. 

C. Buscarino, and D.S. Krause, Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med, 1998. 339(4) 209-15. 

Additional physical studies and calculations have been performed on peroxy-nitrite (Koppenol and Klasinc, 1993 Kraus, 1994)- Part of the infrared spectrum of peroxynitrite anion in a solid state matrix has been reported (Plumb and Edwards, 1991). 

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