Borrelia burgdorferi

Shanafelt, M.C., Hindersson, P., Soderberg, C., Mensi, N., Turck, C.W., Webb, D., Yssel, H., Pertz, G. (1991). T cell and antibody reactivity with the Borrelia burgdorferi 60 kD heat shock protein in Lyme arthritis. J. Immunol. 146, 3985-3992. 

Borrelia recurrentis causes a relapsing fever in humans. Borrelia vincenti is the cause of Vincent s angina in humans, an ulcerative condition of the mouth and gums. Borrelia burgdorferi is the causal organism of the tick-borne Lyme disease. 

Chloroform-methanol extracts of Borrelia burgdorferi were used for the identification of lipids and other related components that could help in the diagnosis of Lyme disease [58]. The provitamin D fraction of skin lipids of rats was purified by PTLC and further analyzed by UV, HPLC, GLC, and GC-MS. MS results indicated that this fraction contained a small amount of cholesterol, lathosterol, and two other unknown sterols in addition to 7-dehydrocholesterol [12]. Two fluorescent lipids extracted from bovine brain white matter were isolated by two-step PTLC using silica gel G plates [59]. PTLC has been used for the separation of sterols, free fatty acids, triacylglycerols, and sterol esters in lipids extracted from the pathogenic fungus Fusarium culmorum [60]. 

Livesley, M. A. Thompson, I. P. Gern, L. Nuttall, P. A. Analysis of intra-specific variation in the fatty acid profiles of Borrelia burgdorferi. J. Gen. Microbiol. 1993, 139, 2197-2201. 

Borrelia burgdorferi 1.44/1637 (43)2) Lyme disease - transmitted to humans by infected deer ticks. This disease is a growing problem... 

Fraser CM, Casjens S, Huang WM et al. Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Nature 1997 390[6660] 580—586. 

Subramanian G, Koonin EV, Aravind L. Comparative genome analysis of the pathogenic spirochetes Borrelia burgdorferi and Treponema pallidum. Infect Im-mun 2000 68(3] 1633-1648. 

Borrelia burgdorferi (choice depends on stage of disease)... 

TLR2 -/- decreased clearance of Borrelia burgdorferi lipoproteins greater susceptibility to S. aureas... 

Borrelia burgdorferi (157), appears to constitute a group of microorganisms, which do not, in contrast to the majority of Gram-negative bacteria, require a typical LPS for growth and multiplication. 

Fig. 6. Distribution of the most common folds in selected bacterial, archaeal, and eukaryotic proteomes. The vertical axis shows the fraction of all predicted folds in the respective proteome. Fold name abbreviations FAD/NAD, FAD/NAD(P)-binding Rossman-like domains TIM, TIM-barrel domains SAM-MTR, S-adenosylmethionine-dependent methyltransferases PK, serine-threonine protein kinases PP-Loop, ATP pyrophosphatases. mge, Mycoplasma genitalium rpr, Rickettsiaprowazekii hh x, Borrelia burgdorferi ctr, Chlamydia trachomatis hpy, Helicobacter pylori tma, Thermotoga maritima ssp, Synechocystis sp. mtu, Mycobacterium tuberculosis eco, Escherichia coli mja, Methanococcus jannaschii pho, Pyrococcus horikoshii see, Saccharomyces cerevisiae, cel, Caenorhabditis elegans.

Fig. 8. Principal component analysis of the distribution of the predicted folds in bacterial, archaeal, and eukaryotic proteomes. (a) First and second principal components (b) third and fourth principal components. Aae, Aquifex aeolicus Mge, Mycoplasm genitalium Mpn, Mycoplasma pneumoniae Rpr, Rickettsia prowazekii Bbu, Borrelia burgdorferi Bsu, Bacillus subtilis, Hin, Haemophilus influenzae, Hpy, Helicobacter pylori Tma, Thermotoga mari-...

Isaacs, R. D. (1994). Borrelia burgdorferi bind to epithelial cell proteoglycans. /. Clin. Invest. 93, 809-819. 

Borrelia burgdorferi North America Ixodes damnum, Ixodes pacificus, Ixodes scapularis... 

Lymerix (rOspA, a lipoprotein found on the surface of Borrelia burgdorferi, the major causative agent of Lyme s disease. Produced in E. coli) Smithkline Beecham L5une disease vaccine... 

L D. Doxycycline is the preferred parenteral tetracycline for the primary state of Lyme disease in adults and children older than 8 years of age. Penicillin V (A) would be ineffective. Erythromycin (B) and clarithromycin (C) also are not effective against Borrelia burgdorferi, the gram-negative anaerobe organism responsible for Lyme disease. 

C. Buscarino, and D.S. Krause, Vaccination against Lyme disease with recombinant Borrelia burgdorferi outer-surface lipoprotein A with adjuvant. Lyme Disease Vaccine Study Group. N Engl J Med, 1998. 339(4) 209-15. 

The complete genome of the Lyme disease pathogen, Borrelia burgdorferi, sequenced, along with the genomes for E. coli and H pylori. Nature (1997). 

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