Kline test

KLINE—TEST METHODS, SPECIFICATIONS, AND STANDARDS FOR PLASTICS... 

In view of the high incidence of false-positive Wassermann and Kline tests, and also of anticomplementary sera in these patients, Coburn and Moore tested the electrophoretically separated globulin fractions for activity with the Wassermann and Kline antigens. The antibody was found to be chiefly in the 7 fraction, partly in the Pz fraction. 

The demonstration unit was later transported to the CECOS faciHty at Niagara Falls, New York. In tests performed in 1985, approximately 3400 L of a mixed waste containing 2-chlorophenol [95-57-8] nitrobenzene [98-95-3] and 1,1,2-trichloroethane [79-00-5] were processed over 145 operating hours 2-propanol was used as a supplemental fuel the temperature was maintained at 615 to 635°C. Another 95-h test was conducted on a PCB containing transformer waste. Very high destmction efficiencies were achieved for all compounds studied (17). A later bench-scale study, conducted at Smith Kline and French Laboratories in conjunction with Modar (18), showed that simulated chemical and biological wastes, a fermentation broth, and extreme thermophilic bacteria were all completely destroyed within detection limits. 

The antidepressant properties of these earlier antidepressants were chance discoveries. Imipramine was first developed as a potential antipsychotic, but when Kuhn (2) tested the clinical efficacy of this agent, he found that it only benefited depressed schizophrenic patients. This observation prompted him to test it in patients who were suffering from melancholia. Iproniazid was developed as an antitubercular drug, but the observation that euphoria was a side effect led George Crane ( 3) to conduct clinical trials, which found it useful in purely depressed patients. A year later, Nathan Kline ( 4), following up on this observation, reported positive results when he administered iproniazid to another depressed group. 

The positive effects of the monoamine oxidase inhibitor isoniazid and the amine reuptake blocker imipramine were both discovered by accident. Isoniazid was being used as an antitubercular drug when patients reports of elation led Nathan Kline to test and to demonstrate its antidepressant power. Ronald Kuhn had synthesized imipramine, a tricyclic molecule, as a possible me-too analog of chlorpromazine. When Kuhn found that it had little or no antipsychotic potential, he tried it out on depressives, and voila They got better. After a while, that is. As with isoniazid, imip-ramine s antidepressant action was evident only after one to four weeks of administration. 

The heat flux was varied for every fixed mass flow rate in order to obtain a series of outlet vapour qualities between 0.2 and 1 with a step of 0.05. Steady state values were monitored using a Hewlett Packard 3421A with a 30 minutes time lapse between each mass flow rate or heat flux change. Averaging was carried out after every 20 values and uncertainties were calculated according to the Kline and McClintock (1953) method. The total electrical power dissipated in the test section was calculated as the product of voltage and current. The variations of R134a thermophysical properties with temperature were calculated with the REFPROP 6.01 software. 

Dr. Love (Smith, Kline French) How well does the animal screening correlate with results of human testing ... 

The project-team approach features a famous success. In 1972, a team led by organic chemist Robert Ganellin and pharmacologist James Black discovered the antiulcer, Hg-antagonist cimetidine at Smith Kline and French (now SmithKline Beecham). Their scientific and commercial success culminated 15 years of research. During this time, some 20 biologists and 50 chemists tested and made 700 compounds, the first 200 of them in 4 years. (By today s combinatorial chemistry standards, a set of 700 new compounds is minute.) Two of these compounds failed one or more clinical studies be-... 

Kline, R. B. Beyond Significance Testing Reforming Data Analysis Methods in Behavioral Research American Psychological Association Washington, D. C., 2004. 

Kank, S.M. and Waller, N.G. 2005. Moderated multiple regressiorr, spurious interaction effects, and IRT. Application of Psychological Measures, 29,87-105. Kline, T.J.B. 2005. Psychological Testing A Practical Approach to Design and Evaluation. Vistaar Publications New Delhi. 

Fry, Michael A., Kline, Jerry D., Prince, John L.,andTanel, Gary A., In-Line KGD Test Speeds Flip Chip Assembly, Electronic Packaging and Production, February 2001, pp. 36-41. 

One disk from each leaf was floated (top-side up) In a petrl dish containing 20 ml of various test solutions (pH 6.0). The petrl dishes were placed In a vacuum chamber (640 mm Hg) for 2 minutes and then removed and Incubated In the dark at 25°C. After the desired times disks were removed, placed In 1 ml of hot Isopropanol and heated to 70°C for 10 min to Inactivate the lipolytic enzinnes. The lipids were extracted and separated by thin layer chromatography as previously described (1). Phosphatidylcholine and dlgalactosyl dlacylglycerol were Identified by comparison with known standards, removed from the TLC plates and analyzed quantitatively (3,4). Trifluoperazine sulfoxide was a generous gift from Smith, Kline, and French Laboratories. 

The authors wish to acknowledge the work of J. Kline and J. Goodykoontz of the NASA Lewis Research Center in setting up and conducting many of the tests. 

Kline, P. The Handbook of Psychological Testing, 2nd edn. Routledge, London (2000)... 

Khera, A.K., Wibberley, D.G. and Dathan, J.G. (1980). Placental and stillbirth tissue lead concentrations in occupationally exposed women. Br. ]. Ind. Med., 37, 394-396 Kirkconnell, S.C. and Hicks, L.E. (1980). Residual effects of lead poisoning on Denver developmental screening test scores. ]. Abnorm. Child Psychol, 8, 257-267 Kline, T.S. (1960). Myocardial changes in lead poisoning. Am. ]. Dis. Child., 99, 48-54 Kotok, D. (1972). Development of children with elevated blood lead levels a controlled study. ]. Pediatr. (St. Louis), 80, 56-71... 

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