Crane, George

The antidepressant properties of these earlier antidepressants were chance discoveries. Imipramine was first developed as a potential antipsychotic, but when Kuhn (2) tested the clinical efficacy of this agent, he found that it only benefited depressed schizophrenic patients. This observation prompted him to test it in patients who were suffering from melancholia. Iproniazid was developed as an antitubercular drug, but the observation that euphoria was a side effect led George Crane ( 3) to conduct clinical trials, which found it useful in purely depressed patients. A year later, Nathan Kline ( 4), following up on this observation, reported positive results when he administered iproniazid to another depressed group. 

Kemp T, Pearce N, Fitzharris P, Crane J, Fergusson D, St George 1, Wickens K, Beasley R. Is infant immunization a risk factor for childhood asthma or allergy Epidemiology 1997 8(6) 678-80. 

Hideo Chiba 14 P. B. Chock 13, 18 Richard I. Christopherson 18 Georges N. Cohen 1 Paul Cohen 15 Philip P. Cohen 14, 18 Carl F. Cori 10, 18 F. L. Crane 20... 

They sure are said Mr. Crane. You take John Burris that runs the store, and George Burris works there, and his son, they s half brothers. And they really looks out for em. They won t let nobody say anything about George Burris. ... 

In 1880 the household of Ervin Crane (25) and Mary Crane (18) included Candacy (9), described as a sister (1880 census). In 1900 a Candasia (probably the same person) was the wife of George Burris. 

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